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Famotidine-13C-d3 Sale

目录号 : GC47331

A neuropeptide with diverse biological activities

Famotidine-13C-d3 Chemical Structure

规格 价格 库存 购买数量
1 mg
¥7,349.00
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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

Famotidine-13C-d3 is intended for use as an internal standard for the quantification of famotidine by GC- or LC-MS. Famotidine is a histamine H2 receptor antagonist with a Ki value of 12 nM in fractionated guinea pig cerebral cortex membranes.1 It is selective for H2 over H1 and muscarinic receptors (Kis = 4 and 28 µM, respectively, in bovine cerebral cortex).2 Famotidine inhibits histamine-induced acid secretion in isolated canine parietal cells (IC50 = 0.6 µM).3 It also suppresses histamine-induced gastric acid secretion in dogs when administered orally and in anesthetized rats when administered intraduodenally (ID50s = 10 and 400 µg/kg, respectively).3 Formulations containing famotidine have been used in the treatment of ulcers, gastroesophageal reflux disease (GERD), and heartburn, as well as to decrease the risk of gastrointestinal toxicity associated with non-steroidal anti-inflammatory drugs (NSAIDs).

1.Gajtkowski, G.A., Norris, D.B., Rising, T.J., et al.Specific binding of 3H-tiotidine to histamine H2 receptors in guinea pig cerebral cortexNature304(5921)65-67(1983) 2.Kubo, N., Shirakawa, S., Kuno, T., et al.Antimuscarinic effects of antihistamines: Quantitative evaluation by receptor-binding assayJpn. J. Pharmacol.43(3)277-282(1987) 3.Nagaya, H., Inatomi, N., and Satoh, H.Differences in the antisecretory actions of the proton pump inhibitor AG-1749 (lansoprazole) and the histamine H2-receptor antagonist famotidine in rats and dogsJpn. J. Pharmacol.55(4)425-436(1991)

Chemical Properties

Cas No. N/A SDF
Canonical SMILES NS(N[13C](C([2H])C([2H])([2H])SCC1=CSC(NC(N)=N)=N1)=N)(=O)=O
分子式 C7[13C]H12D3N7O2S3 分子量 341.5
溶解度 DMF: soluble,DMSO: soluble,Methanol: soluble 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.9283 mL 14.6413 mL 29.2826 mL
5 mM 0.5857 mL 2.9283 mL 5.8565 mL
10 mM 0.2928 mL 1.4641 mL 2.9283 mL
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