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F16 Sale

目录号 : GC14791

A potential antitumor agent

F16 Chemical Structure

Cas No.:36098-33-6

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5mg 待询 待询
10mg
¥495.00
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50mg
¥1,710.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

F16 is a small, cationic, lipophilic, and fluorescent molecule capable of binding preferentially to mitochondrial membranes and disrupts their function. F16 is a potential antitumor agent.

F16 affected growth in some mouse and human breast cancer cell lines. F16 resulted in a dramatic decrease in the number of cells in S phase and an increase in the percentage of cells in G1 phase [1]. Prolonged incubation with 3 μM F16 led to increased cell death of F16-sensitive cells but not of F16-resistant ones. F16 accumulation in mitochondria induced mitochondrial damage characterized by imbalance of volumetric homeostasis, failure to synthesize ATP, cytochrome c release and increased production of reactive oxy gen species [1]. F16 incubation decreased the cellular ATP pool in both parental EpH4-A6 and Bcl-2-overexpressing EpH4-A6.C13 and EpH4-A6.C18 cells in a time-dependent manner [1]. Treatment with F16 promoted early release of cytochrome c in transformed EpH4-A6 cells. Treatment with F16 (0.3-3 μM) resulted in the characteristic apoptotic DNA laddering in the EpH4-A6 cells. F16-Induced mitochondrial dysfunction triggers apoptosis or necrosis. F16 induced necrosis in various cell lines resistant to apoptosis [2].

References:
[1] Fantin V R, Berardi M J, Scorrano L, et al.  A novel mitochondriotoxic small molecule that selectively inhibits tumor cell growth[J]. Cancer cell, 2002, 2(1): 29-42.
[2] Fantin V R, Leder P.  F16, a mitochondriotoxic compound, triggers apoptosis or necrosis depending on the genetic background of the target carcinoma cell[J]. Cancer research, 2004, 64(1): 329-336.

Chemical Properties

Cas No. 36098-33-6 SDF
化学名 4-[(1E)-2-(1H-indol-3-yl)ethenyl]-1-methyl-pyridinium iodide
Canonical SMILES [H]N1C=C(/C=C/C2=CC=[N+](C)C=C2)C3=CC=CC=C31.[I-]
分子式 C16H15N2 • I 分子量 362.2
溶解度 ≤500μg/ml in ethanol;20mg/ml in DMSO;25mg/ml in dimethyl formamide 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
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1 mM 2.7609 mL 13.8045 mL 27.6091 mL
5 mM 0.5522 mL 2.7609 mL 5.5218 mL
10 mM 0.2761 mL 1.3805 mL 2.7609 mL
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