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Exo1 Sale

(Synonyms: Exocytic Inhibitor 1, NSC 214045) 目录号 : GC15751

A reversible inhibitor of exocytosis

Exo1 Chemical Structure

Cas No.:461681-88-9;75541-83-2

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10mM (in 1mL DMSO) 待询 待询
10mg
¥540.00
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50mg
¥1,890.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

IC50: about 20 μM for exocytosis

Exo1 is a chemical inhibitor of the exocytic pathway.

The development of a cellular organism is mainly controlled at the transcriptional level but it was also shown to require the transport of membrane and proteins via the exocytic pathway to the plasma membrane and the extracellular medium.

In vitro: A Previous study using phenotypic screen to search for drug-like molecules that could interfere with specific steps in membrane traffic. Screening resulted in the identification of Exo1, which could induce a rapid collapse of the Golgi to the endoplasmic reticulum, therefore inhibiting the traffic emanating from the endoplasmic reticulum acutely. In addition, similar to Brefeldin A (BFA), Exo1 could induce the quick release of ADP-ribosylation factor (ARF) 1 from Golgi membranes but had minimal effect on the organization of the trans-Golgi network. These data suggested that Exo1 acted by a different mechanism from BFA. However, unlike BFA, Exo1 could not induce the ADP-ribosylation of CtBPBars50 and could not interfere with the activity of guanine nucleotide exchange factors neither. Thererfore, Exo1 allowed the fatty acid exchange activity of Bars50 to be distinguished from ARF1 activity [1].

In vivo: Currently, there is no animal data reported.

Clinical trial: Up to now, Exo1 is still in the preclinical development stage.

Reference:
[1] Feng Y,Yu S,Lasell TK,Jadhav AP,Macia E,Chardin P,Melancon P,Roth M,Mitchison T,Kirchhausen T.  Exo1: a new chemical inhibitor of the exocytic pathway. Proc Natl Acad Sci U S A.2003 May 27;100(11):6469-74.

Chemical Properties

Cas No. 461681-88-9;75541-83-2 SDF
别名 Exocytic Inhibitor 1, NSC 214045
化学名 methyl 2-(4-fluorobenzamido)benzoate
Canonical SMILES FC1=CC=C(C=C1)C(NC2=CC=CC=C2C(OC)=O)=O
分子式 C15H12FNO3 分子量 273.26
溶解度 <6.83mg/ml in ethanol; <27.33mg/ml in DMSO 储存条件 Store at -20°C
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1 mg 5 mg 10 mg
1 mM 3.6595 mL 18.2976 mL 36.5952 mL
5 mM 0.7319 mL 3.6595 mL 7.319 mL
10 mM 0.366 mL 1.8298 mL 3.6595 mL
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