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Emeramide (BDTH2) Sale

(Synonyms: N,N'-二(2-巯基乙基)间苯二甲酰胺,BDTH2) 目录号 : GC31671

An antioxidant heavy metal chelator

Emeramide (BDTH2) Chemical Structure

Cas No.:351994-94-0

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥491.00
现货
100mg
¥446.00
现货
500mg
¥982.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

Emeramide is an antioxidant heavy metal chelator.1 It prevents methylmercury-induced glutathione (GSH) loss, and cytotoxicity to, isolated mouse aortic endothelial cells when used at a concentration of 50 ?M. Emeramide (50 ?M) also prevents reactive oxygen species (ROS) production and cytotoxicity induced by bleomycin in primary bovine pulmonary artery endothelial cells.2 It increases survival of rats in a model of mercury chloride-induced toxicity when administered at a dose of 2 mg/kg.3

1.Secor, J.D., Kotha, S.R., Gurney, T.O., et al.Novel lipid-soluble thiol-redox antioxidant and heavy metal chelator, N,N'-bis(2-mercaptoethyl)isophthalamide (NBMI) and phospholipase D-specific inhibitor, 5-fluoro-2-indolyl des-chlorohalopemide (FIPI) attenuate mercury-induced lipid signaling leading to protection against cytotoxicity in aortic endothelial cellsInt. J. Toxicol.30(6)619-638(2011) 2.Patel, R.B., Kotha, S.R., Sauers, L.A., et al.Thiol-redox antioxidants protect against lung vascular endothelial cytoskeletal alterations caused by pulmonary fibrosis inducer, bleomycin: Comparison between classical thiol-protectant, N-acetyl-L-cysteine, and novel thiol antioxidant, N,N'-bis-2-mercaptoethyl isophthalamideToxicol. Mech. Methods22(5)383-396(2012) 3.Clarke, D., Buchanan, R., Gupta, N., et al.Amelioration of acute mercury toxicity by a novel, non-toxic lipid soluble chelator N,N'bis-(2-mercaptoethyl)isophthalamide: Effect on animal survival, health, mercury excretion and organ accumulationToxicol. Environ. Chem.94(3)616-640(2012)

Chemical Properties

Cas No. 351994-94-0 SDF
别名 N,N'-二(2-巯基乙基)间苯二甲酰胺,BDTH2
Canonical SMILES O=C(C1=CC=CC(C(NCCS)=O)=C1)NCCS
分子式 C12H16N2O2S2 分子量 284.4
溶解度 DMSO : 100 mg/mL (351.62 mM);Water : < 0.1 mg/mL (insoluble) 储存条件 Store at -20°C,unstable in solution, ready to use.
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

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1 mg 5 mg 10 mg
1 mM 3.5162 mL 17.5809 mL 35.1617 mL
5 mM 0.7032 mL 3.5162 mL 7.0323 mL
10 mM 0.3516 mL 1.7581 mL 3.5162 mL
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