Duoperone
(Synonyms: 度奥哌隆) 目录号 : GC31031
Duoperone是一种安定剂，同时在动物模型中，也是一种止吐剂。
Cas No.:62030-88-0
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Duoperone is a neuroleptic agent and also a antiemetic agent in animal models.
Duoperone blocks d-amphetamine lethality in mice under aggregated conditions when the pretreatment interval is between one hour and seven days. ABR-6646 produces catalepsy in rats. The onset of this effect is delayed and the duration is prolonged when compared with that of chlorpromazine. Apomorphine-induced pivoting in mice with unilateral lesions of the caudate nucleus is suppressed by ARR-6646[1].
[1]. Johnson DN, et al. AHR-6646: a new, long-acting neuroleptic. Prog Neuropsychopharmacol. 1979;3(5-6):513-20.
| Cas No. | 62030-88-0 | SDF | |
| 别名 | 度奥哌隆 | ||
| Canonical SMILES | O=C(C1=CC=C(F)C=C1)C2CCN(CCCN3C4=C(C=CC=C4)SC5=CC=C(C(F)(F)F)C=C35)CC2 | ||
| 分子式 | C28H26F4N2OS | 分子量 | 514.58 |
| 溶解度 | Soluble in DMSO | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.9433 mL | 9.7167 mL | 19.4333 mL |
| 5 mM | 0.3887 mL | 1.9433 mL | 3.8867 mL |
| 10 mM | 0.1943 mL | 0.9717 mL | 1.9433 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Determination of duoperone in plasma by high-performance liquid chromatography
AHR-6646: a new, long-acting neuroleptic
1. AHR-6646 blocked d-amphetamine lethality in mice under aggregated conditions when the pretreatment interval was between one hour and seven days. 2. Conditioned avoidance responding in mice and cats was suppressed by AHR-6646 in doses that did not impair escape behavior. The duration of this effect was markedly prolonged. 3. AHR-6646 produced catalepsy in rats. The onset of this effect was delayed and the duration was prolonged when compared with that of chlorpromazine. 4. Apomorphine-induced pivoting in mice with unilateral lesions of the caudate nucleus was suppressed by AHR-6646. 5. AHR-6646 was a potent antiemetic agent in dogs, with a delayed onset and prolonged duration of action.