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Difloxacin HCl Sale

(Synonyms: 盐酸二氟沙星) 目录号 : GC16213

A fluoroquinolone antibiotic

Difloxacin HCl Chemical Structure

Cas No.:91296-86-5

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥357.00
现货
1g
¥431.00
现货
5g
¥1,365.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

Quality Control & SDS

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产品描述

Difloxacin HCl is a quinolone antimicrobial antibiotic [1].
Quinolone antibiotics target bacterial DNA gyrase which is required during DNA replication, subsequent DNA synthesis and ultimately cell division.
In unselected cultured human neuroblastoma cells, difloxacin (50 microg/ml) increased sensitivity to the multidrug resistance-associated protein (MRP) substrates. Daunorubicin, doxorubicin, vincristine and potassium antimony tartrate is proportional to the level of MRP expression, which proves that difloxacin HCl reverse drug resistance in human neuroblastoma cells [1].
Difloxacin HCl is a quinolone antimicrobial antibiotic and may reverse drug resistance in human neuroblastoma cells. Difloxacin HCl is commonly used in clinical in vitro antimicrobial susceptibility tests against gram-positive and gram-negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients.
References:
[1]. Norris MD, Madafiglio J, Gilbert J, et al. Reversal of multidrug resistance-associated protein-mediated drug resistance in cultured human neuroblastoma cells by the quinolone antibiotic difloxacin. Med Pediatr Oncol, 2001, 36(1): 177-180.

Chemical Properties

Cas No. 91296-86-5 SDF
别名 盐酸二氟沙星
化学名 6-fluoro-1-(4-fluorophenyl)-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid
Canonical SMILES CN1CCN(CC1)C2=C(C=C3C(=C2)N(C=C(C3=O)C(=O)O)C4=CC=C(C=C4)F)F
分子式 C21H19F2N3O3 HCl 分子量 435.86
溶解度 ≥ 9.15mg/mL in DMSO with gentle warming 储存条件 Store at 0-6°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.2943 mL 11.4716 mL 22.9431 mL
5 mM 0.4589 mL 2.2943 mL 4.5886 mL
10 mM 0.2294 mL 1.1472 mL 2.2943 mL
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