D-α-Tocopheryl Quinone |
目录号 GC49868 |
Sample solution is provided at 25 µL, 10mM.
Quality Control & SDS
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Purity: >98.00%
- COA (Certificate Of Analysis)
- Datasheet
D-α-Tocopheryl quinone is an active oxidative metabolite of vitamin E and an essential cofactor for mitochondrial fatty acid desaturases.1 It has antioxidant activity in oxygen radical absorbance capacity (ORAC) and radical trapping assays when used at a concentration of 25 µM and inhibits ferroptosis induced by (1S,3R)-RSL3 in Q7 cells (EC50 = 0.233 µM).2 D-α-Tocopheryl quinone (20 mg/kg) decreases serum malondialdehyde (MDA) and blood glucose levels and restores the number and diversity of intestinal microflora in a rat model of high cholesterol and cholate diet-induced non-alcoholic steatohepatitis (NASH).3
1.Infante, J.P.A function for the vitamin E metabolite alpha-tocopherol quinone as an essential enzyme cofactor for the mitochondrial fatty acid desaturasesFEBS Lett.446(1)1-5(1999) 2.Hinman, A., Holst, C.R., Latham, J.C., et al.Vitamin E hydroquinone is an endogenous regulator of ferroptosis via redox control of 15-lipoxygenase.PLoS One13(8)e0201369(2018) 3.Sun, T., Zhang, B., Ru, Q.-J., et al.Tocopheryl quinone improves non-alcoholic steatohepatitis (NASH) associated dysmetabolism of glucose and lipids by upregulating the expression of glucagon-like peptide 1 (GLP-1) via restoring the balance of intestinal flora in ratsPharm. Biol.59(1)723-731(2021)
Cas No. | 4/8/7559 | SDF | Download SDF |
别名 | N/A | ||
化学名 | N/A | ||
Canonical SMILES | CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC[C@@](C)(O)CCC1=C(C(C(C)=C(C1=O)C)=O)C | ||
分子式 | C29H50O3 | 分子量 | 446.7 |
溶解度 | DMF: 12 mg/mL,DMSO: 10 mg/mL,Ethanol: 16 mg/mL | 储存条件 | -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. | ||
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量) | ||||||||||
给药剂量 | mg/kg | 动物平均体重 | g | 每只动物给药体积 | ul | 动物数量 | 只 | |||
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系GLPBIO为您提供正确的澄清溶液配方) | ||||||||||
% DMSO % % Tween 80 % ddH2O | ||||||||||
计算重置 |
计算结果:
工作液浓度: mg/ml;
DMSO母液配制方法: mg 药物溶于 μL DMSO溶液(母液浓度 mg/mL,
体内配方配制方法:取 μL DMSO母液,加入 μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入 μL ddH2O,混匀澄清。
1. 首先保证母液是澄清的;
2.
一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。