Home>>D-α-Tocopheryl Quinone

D-α-Tocopheryl Quinone

目录号 GC49868

规格 价格 库存 购买数量
10 mg
¥350.00
现货
50 mg
¥1,666.00
现货
100 mg
¥2,282.00
现货
250 mg
¥5,250.00
现货

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Sample solution is provided at 25 µL, 10mM.

质量管理

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产品描述

D-α-Tocopheryl quinone is an active oxidative metabolite of vitamin E and an essential cofactor for mitochondrial fatty acid desaturases.1 It has antioxidant activity in oxygen radical absorbance capacity (ORAC) and radical trapping assays when used at a concentration of 25 µM and inhibits ferroptosis induced by (1S,3R)-RSL3 in Q7 cells (EC50 = 0.233 µM).2 D-α-Tocopheryl quinone (20 mg/kg) decreases serum malondialdehyde (MDA) and blood glucose levels and restores the number and diversity of intestinal microflora in a rat model of high cholesterol and cholate diet-induced non-alcoholic steatohepatitis (NASH).3

1.Infante, J.P.A function for the vitamin E metabolite alpha-tocopherol quinone as an essential enzyme cofactor for the mitochondrial fatty acid desaturasesFEBS Lett.446(1)1-5(1999) 2.Hinman, A., Holst, C.R., Latham, J.C., et al.Vitamin E hydroquinone is an endogenous regulator of ferroptosis via redox control of 15-lipoxygenase.PLoS One13(8)e0201369(2018) 3.Sun, T., Zhang, B., Ru, Q.-J., et al.Tocopheryl quinone improves non-alcoholic steatohepatitis (NASH) associated dysmetabolism of glucose and lipids by upregulating the expression of glucagon-like peptide 1 (GLP-1) via restoring the balance of intestinal flora in ratsPharm. Biol.59(1)723-731(2021)

Chemical Properties

Cas No. 4/8/7559 SDF Download SDF
别名 N/A
化学名 N/A
Canonical SMILES CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC[C@@](C)(O)CCC1=C(C(C(C)=C(C1=O)C)=O)C
分子式 C29H50O3 分子量 446.7
溶解度 DMF: 12 mg/mL,DMSO: 10 mg/mL,Ethanol: 16 mg/mL 储存条件 -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

动物体内配方计算器 (澄清溶液)

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