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Cyclic di-GMP (sodium salt) Sale

(Synonyms: c-di-GMP, Cyclic diguanylate, 3',5'-Cyclic diguanylic acid) 目录号 : GC19526

A bacterial second messenger and cyclic dinucleotide

Cyclic di-GMP (sodium salt) Chemical Structure

Cas No.:2222132-40-1

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1mg
¥2,475.00
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5mg
¥7,425.00
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10mg
¥11,880.00
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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

Cyclic di-GMP is a second messenger in bacteria involved in diverse prokaryotic processes, including biofilm formation, motility, virulence, and cell cycling.[1],[2] In eukaryotic cells, cyclic di-GMP is detected by and binds to the transmembrane protein stimulator of interferon genes (STING; Kd = 1.21 µM), leading to activation of the innate immune system.[3],[4] It has been used at a preset molar ratio with STING dimers in binding assays to determine the binding constants of particularly tight binding partners, such as 2’3’-cGAMP. Cyclic di-GMP induces IFN-β mRNA expression in vitro (EC50 = 537.8 nM) but less potently than 2’3’-cGAMP, 3’2’-cGAMP, 3’3’-cGAMP, and 2’2’-cGAMP.

Reference:
[1]. Römling, U., Galperin, M.Y., and Gomelsky, M. Cyclic di-GMP: The first 25 years of a universal bacterial second messenger Microbiology and Molecular Biology Reviews 77(1), 1-52 (2013).
[2]. Martínez, L.C., and Vadyvaloo, V. Mechanisms of post-transcriptional gene regulation in bacterial biofilms Front.Cell.Neurosci. 4(38), 1-15 (2014).
[3]. Schaap, P. Cyclic di-nucleotide signaling enters the eukaryote domain IUBMB Life 65(11), 897-903 (2013).
[4]. Zhang, X., Shi, H., Wu, J., et al. Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING Mol. Cell 51(2), 226-235 (2015).


  

Chemical Properties

Cas No. 2222132-40-1 SDF
别名 c-di-GMP, Cyclic diguanylate, 3',5'-Cyclic diguanylic acid
化学名 guanylyl-(3'→5')-3'-guanylic acid, cyclic nucleotide, disodium salt
Canonical SMILES O=C1NC(N)=NC2=C1N=CN2[C@@H]([C@@H]3O)O[C@@]([H])([C@]3(OP([O-])(OC[C@]([H])([C@]4(O5)[H])O[C@H]([C@@H]4O)N6C(N=C(N7)N)=C(N=C6)C7=O)=O)[H])COP5([O-])=O.[Na+].[Na+]
分子式 C20H22N10O14P22Na 分子量 734.4
溶解度 1mg/mL in water 储存条件 Store at -80°C, protect from light, stored under nitrogen
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

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1 mg 5 mg 10 mg
1 mM 1.3617 mL 6.8083 mL 13.6166 mL
5 mM 0.2723 mL 1.3617 mL 2.7233 mL
10 mM 0.1362 mL 0.6808 mL 1.3617 mL
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