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Curculigoside B Sale

(Synonyms: 仙茅苷乙) 目录号 : GC60732

CurculigosideB是从虎杖中分离得到的酚苷类化合物,能促进成骨细胞增殖,减少骨吸收坑面积,减少破骨细胞形成和TRAP活性。具有抗骨质疏松和抗氧化活性。

Curculigoside B Chemical Structure

Cas No.:143601-09-6

规格 价格 库存 购买数量
1mg
¥1,800.00
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产品描述

Curculigoside B, a phenolic glycoside isolated from Curculigo orchioides, enhances the osteoblast proliferation, decreases the area of bone resorption pit, osteoclastic formation and TRAP activity. Antiosteoporotic and antioxidative activities[1].

[1]. Jiao L, et al. Antiosteoporotic activity of phenolic compounds from Curculigo orchioides. Phytomedicine. 2009;16(9):874-881.

Chemical Properties

Cas No. 143601-09-6 SDF
别名 仙茅苷乙
Canonical SMILES O=C(C(C(O)=CC=C1)=C1OC)OCC(C=C2O)=C(C=C2)O[C@@H]([C@@H]([C@H]3O)O)O[C@@H]([C@H]3O)CO
分子式 C21H24O11 分子量 452.41
溶解度 储存条件 Store at -20°C
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1 mg 5 mg 10 mg
1 mM 2.2104 mL 11.0519 mL 22.1038 mL
5 mM 0.4421 mL 2.2104 mL 4.4208 mL
10 mM 0.221 mL 1.1052 mL 2.2104 mL
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Research Update

Two new benzylbenzoate glucosides from Curculigo orchioides

Fitoterapia 2006 Sep;77(6):416-9.PMID:16814485DOI:10.1016/j.fitote.2006.05.013.

An extract from in vitro cultures of Curculigo orchioides grown as bulbils in shake flasks, afforded two new glucosides of substituted benzylbenzoate - curculigoside C (3) and curculigoside D (4) - together with two known compounds - curculigoside A (1) and Curculigoside B (2). Their structures were elucidated on the basis of spectral evidence, in particular by using 2D NMR methods. Their vasoactive properties were assessed in isolated rat aortic rings.

Antiosteoporotic activity of phenolic compounds from Curculigo orchioides

Phytomedicine 2009 Sep;16(9):874-81.PMID:19328665DOI:10.1016/j.phymed.2009.01.005.

Six phenolic compounds isolated from Curculigo orchioides, including 2,6-dimethoxy benzoic acid (1), curculigoside A (2), Curculigoside B (3), curculigine A (4), curculigine D (5) and 3,3',5,5'-tetramethoxy-7,9':7',9-diepoxylignan-4,4'-di-O-beta-D-glucopyranoside (6), together with the ethanol extract of Curculigo orchioides were evaluated for their activity on osteoblasts in neonatal rat calvaria cultures and multinucleated osteoclasts derived from rat marrow cells so as to characterize the antiosteoporotic components of this plant and explore the relationship of chemical structure with antiosteoporotic activity. The proliferation of osteoblast was assayed by MTT methods. The activity of ALP (alkaline phosphatase) and TRAP (tartrate-resistant acid phosphatase) was measured by p-nitrophenyl sodium phosphate assay. The TRAP stain was used to identify osteoclast in morphology. The resorption pit area on the bone slices formed by osteoclast was measured by computer image processing. The ethanol extract exhibited stimulatory effect on both the osteoblast proliferation and the ALP activity. Six compounds all increased the osteoblast proliferation, and compounds (1), (2) and (4) also slightly increased the osteoblastic ALP activity. Compounds (1), (2), (3), (6) and the ethanol extract decreased area of bone resorption pit, osteoclastic formation and TRAP activity. These results indicated that phenolic compounds are antiosteoporotic chemical constituents from Curculigo orchioides, and their activities are related with chemical structures.

Antioxidative phenols and phenolic glycosides from Curculigo orchioides

Chem Pharm Bull (Tokyo) 2005 Aug;53(8):1065-7.PMID:16079552DOI:10.1248/cpb.53.1065.

A new orcinol glucoside, orcinol-1-O-beta-D-apiofuranosyl-(1-->6)-beta-D-glucopyranoside (3), was isolated from the rhizomes of Curculigo orchioides GAERTN., together with seven known compounds: orcinol glucoside (1), orcinol-1-O-beta-D-glucopyranosyl-(1-->6)-beta-D-glucopyranoside (2), curculigoside (4), Curculigoside B (5), curculigoside C (6), 2,6-dimethoxyl benzoic acid (7), and syringic acid (8). The structures of these compounds were elucidated using spectroscopic methods. The antioxidant activities of these isolated compounds were evaluated by colorimetric methods based on their scavenging effects on hydroxyl radicals and superoxide anion radicals, respectively. All the compounds showed potent antioxidative activities and the structure-activity relationship is discussed.

[Phenyl glycosides from Curculigo orchioides]

Yao Xue Xue Bao 1992;27(5):353-7.PMID:1442056doi

One new phenyl glycoside and two new chlorophenyl glycosides were isolated from rhizomes of Curculigo orchioides (Chinese name: Xian Mao, Hypoxidaceae). Based on HRMS, FABMS, 1H-, 13C-NMR and other spectral data as well as chemical evidence, the structures of Curculigoside B, curculigine B and C were elucidated to be 2-beta-D-glucopyranosyloxy-5-hydroxybenzyl-2'-methoxy-6'-hydroxybe nzoate (I),24-dichloro-3-methyl-5-methoxy-phenol-O-beta-D-apiofuranosyl (1-6)-beta-D-glucopyanoside (III) and 2,4,6-trichloro-3-methyl-5-methoxyphenol-O-beta-D-xylopyranosyl (1-6)-beta-D-glucopyranoside (IV), respectively.