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Corynecin II Sale

(Synonyms: 棒状杆菌素II) 目录号 : GC40079

A chloramphenicol-like antibiotic

Corynecin II Chemical Structure

Cas No.:35098-52-3

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1mg
¥1,696.00
现货
5mg
¥5,088.00
现货

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Sample solution is provided at 25 µL, 10mM.

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产品描述

Corynecin II is a chloramphenicol-like antibiotic originally isolated from Corynebacterium. It inhibits the growth of Gram-positive and Gram-negative bacteria, including S. faecalis, S. aureus, B. subtilis, E. coli, P. aeruginosa, P. vulgaris, S. sonnei, S. typhosa, and K. pneumoniae (MICs = 5.2-83 μg/ml).

Chemical Properties

Cas No. 35098-52-3 SDF
别名 棒状杆菌素II
Canonical SMILES OC[C@@H](NC(CC)=O)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1
分子式 C12H16N2O5 分子量 268.3
溶解度 Soluble in DMSO 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 3.7272 mL 18.6359 mL 37.2717 mL
5 mM 0.7454 mL 3.7272 mL 7.4543 mL
10 mM 0.3727 mL 1.8636 mL 3.7272 mL
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Research Update

Metabolites of a blocked chloramphenicol producer

J Nat Prod 2003 Jan;66(1):62-6.PMID:12542347DOI:10.1021/np020306e

Addition of p-aminophenylalanine (4), an advanced biosynthetic precursor of the antibiotic chloramphenicol (5), to a Streptomyces venezuelae pabAB mutant (VS629) restored chloramphenicol production and led to formation of the non-chlorinated analogue Corynecin II (6) and four acetanilide derivatives: p-(acetylamino)phenylalanine (7), p-(acetylamino)benzyl alcohol (13), p-(acetylamino)benzoic acid (14), and p-(acetylamino)phenol (acetaminophen, 16). Metabolite structures were deduced from NMR and MS-MS data and established by chromatographic and spectroscopic comparisons with authentic samples. Reference compound 13 was synthesized by reducing the acid chloride of 14. Shunt pathways are proposed to account for the formation of the metabolites from p-aminophenylalanine.