|Compound 48/80 (hydrochloride) 目录号 GC43305|
Sample solution is provided at 25 µL, 10mM.
|Cas No.||848035-21-2||SDF||Download SDF|
|分子式||C32H45N3O3 • 3HCl||分子量||629.1|
|溶解度||100mM in water||储存条件||Store at -20°C|
|General tips||For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.|
|Shipping Condition||Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
Compound 48/80 is a condensation product of N-methyl-p-methoxyphenethylamine with formaldehyde that causes histamine degranulation from mast cells. Compound 48/80 also inhibits human platelet aggregation through suppression of calmodulin (CaM) (IC50 = 0.41 μg/ml for CaM-dependent Ca2+-transporter ATPase activity) and phospholipase C (IC50s = 2.1 and 5.0 μg/ml for cytosolic and particulate phosphatidylinositol-specific activities, respectively).,
. Rothschild, A.M. Mechanisms of histamine release by compound 48/80. Br. J. Pharmac. 38(1), 253-262 (1970).
. Adamczyk-Engelmann, P., and Gietzen, K. Induction of histamine release and calmodulin antagonism are two distinct properties of compound 48/80. Cell Calcium 10(2), 93-99 (1989).
. Bronner, C., Charles, W., Didier, M., et al. Compound 48/80 is a potent inhibitor of phospholipase C and a dual modulator of phospholipase A2 from human platelet. Biochim Biophys. Acta. 920(3), 301-305 (1987).