Home>>Signaling Pathways>> Others>>Prothrombin (474-477) [Mus musculus]
Prothrombin (474-477) [Mus musculus] 目录号 GP10053

Role in coagulation cascade

规格 价格 库存 购买数量
1mg
¥284.00
现货
5mg
¥935.00
现货
10mg
¥1,491.00
现货
25mg
¥2,006.00
现货

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Sample solution is provided at 25 µL, 10mM.

质量管理

Quality Control & SDS

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Chemical Properties

Cas No. N/A SDF
别名 H2N-Tyr-Ile-His-Pro-OH
化学名 N/A
Canonical SMILES OC1=CC=C(C[C@H](N)C(N[C@@H]([C@H](C)CC)C(NC(CC2=CNC=N2)C(N3CCC[C@]3([H])C(O)=O)=O)=O)=O)C=C1
分子式 C26H36N6O6 分子量 528.6
溶解度 ≥ 52.9mg/mL in DMSO 储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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产品描述

Prothrombin (coagulation factor II) (H2N-Tyr-Ile-His-Pro-OH) is produced in the liver and is post-translationally modified in a vitamin K-dependent reaction that converts ten glutamic acids on prothrombin into gamma-carboxyglutamic acid (Gla).

Prothrombin is proteolytically cleaved to form thrombin in the coagulation cascade, which ultimately results in the stemming of blood loss. Thrombin in turn acts as a serine protease that converts soluble fibrinogen into insoluble strands of fibrin, as well as catalyzing many other coagulation-related reactions. [1]

Activation of prothrombin is crucial in physiological and pathological coagulation. Various rare diseases involving prothrombin have been described (e.g., hypoprothrombinemia). Anti-prothrombin antibodies in autoimmune disease may be a factor in the formation of the lupus anticoagulant, also known as antiphospholipid syndrome. Hyperprothrombinemia can be caused by the G20210A mutation. Thus, manipulation of prothrombin is central to the mode of action of most anticoagulants.

References:
1. Royle NJ, Irwin DM, Koschinsky ML, MacGillivray RT, Hamerton JL (May 1987). "Human genes encoding prothrombin and ceruloplasmin map to 11p11-q12 and 3q21-24, respectively". Somat. Cell Mol. Genet. 13 (3): 285–92.