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Clomiphene citrate Sale

(Synonyms: 枸橼酸氯米芬; Clomifene citrate) 目录号 : GC15366

A selective estrogen receptor modulator

Clomiphene citrate Chemical Structure

Cas No.:50-41-9

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥450.00
现货
500mg
¥360.00
现货
1g
¥450.00
现货
5g
¥810.00
现货

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Sample solution is provided at 25 µL, 10mM.

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产品描述

Clomiphene citrate (Clomifene citrate) is a selective estrogen receptor modulator.Target: Estrogen Receptor/ERRClomifene citrate (CC) acted as an estrogen antagonist regardless of the concentration of E2 added together. In conclusion, CC acts as an estrogen agonist/antagonist via ER alpha in a coexisting estrogen concentration-dependent way whereas it acts as an estrogen antagonist via ER beta whether or not estrogen is present [1]. Clomiphene was effective in increasing pregnancy rate compared to placebo (OR 5.8, 95% CI 1.6 to 21.5) as was clomiphene plus dexamethasone treatment (OR 9.46, 95% CI 5.1 to 17.7) compared to clomiphene alone. A significant improvement in the pregnancy rate was reported for clomiphene plus combined oral contraceptives versus clomiphene alone. No evidence of a difference in effect on pregnancy rate was found with any of the other comparisons [2].

References:
[1]. Kurosawa, T., et al., Clomiphene citrate elicits estrogen agonistic/antagonistic effects differentially via estrogen receptors alpha and beta. Endocr J, 2010. 57(6): p. 517-21.
[2]. Brown, J., et al., Clomiphene and anti-oestrogens for ovulation induction in PCOS. Cochrane Database Syst Rev, 2009(4): p. CD002249.

Chemical Properties

Cas No. 50-41-9 SDF
别名 枸橼酸氯米芬; Clomifene citrate
化学名 2-[4-[(Z)-2-chloro-1,2-diphenylethenyl]phenoxy]-N,N-diethylethanamine;2-hydroxypropane-1,2,3-tricarboxylic acid
Canonical SMILES CCN(CC)CCOC1=CC=C(C=C1)C(=C(C2=CC=CC=C2)Cl)C3=CC=CC=C3.C(C(=O)O)C(CC(=O)O)(C(=O)O)O
分子式 C26H28ClNO.C6H8O7 分子量 598.08
溶解度 ≥ 23mg/mL in DMSO 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 1.672 mL 8.3601 mL 16.7202 mL
5 mM 0.3344 mL 1.672 mL 3.344 mL
10 mM 0.1672 mL 0.836 mL 1.672 mL
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