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cis-Vaccenic Acid methyl ester Sale

(Synonyms: 顺式-11-十八烯酸甲酯) 目录号 : GC40344

A methyl ester form of cis-vaccenic acid

cis-Vaccenic Acid methyl ester Chemical Structure

Cas No.:1937-63-9

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产品描述

cis-Vaccenic acid methyl ester is a methyl ester form of the monounsaturated fatty acid cis-vaccenic acid . It inhibits sodium influx in mouse brain synaptic plasma membranes, which is positively correlated with an increase in the disordering of membrane lipids. It has been used as an internal standard for the quantification of cis-vaccenic acid in A. mollis by LC-MS and in hempseed oil by GC-MS.

Chemical Properties

Cas No. 1937-63-9 SDF
别名 顺式-11-十八烯酸甲酯
Canonical SMILES O=C(OC)CCCCCCCCC/C=C\CCCCCC
分子式 C19H36O2 分子量 296.5
溶解度 DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 100 mg/ml 储存条件 Store at -20°C
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1 mg 5 mg 10 mg
1 mM 3.3727 mL 16.8634 mL 33.7268 mL
5 mM 0.6745 mL 3.3727 mL 6.7454 mL
10 mM 0.3373 mL 1.6863 mL 3.3727 mL
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Research Update

Effects of ethanol and barbiturates on Ca2+-ATPase activity of erythrocyte and brain membranes

Biochem Pharmacol 1983 Sep 15;32(18):2787-91.PMID:6226291DOI:10.1016/0006-2952(83)90093-x.

Exposure to ethanol or pentobarbital in vitro stimulated the ATP-dependent efflux of calcium from human red blood cells (RBC) and the Ca2+-ATPase activity of RBC and rat brain synaptic plasma membranes (SPM). These effects were obtained with concentrations of ethanol (50 mM) and pentobarbital (60 microM) associated with intoxication in vivo. The enhancement of SPM Ca2+-ATPase by ethanol was due to an increase in the apparent affinity of the enzyme for calcium with no change in the maximum velocity. SPM Ca2+-ATPase was also stimulated by an unsaturated fatty acid, cis-Vaccenic Acid methyl ester (cis-VAME). The membrane-disordering effects of ethanol, four barbiturates and cis-VAME were evaluated in SPM using the fluorescent probe molecule 1,6-diphenyl-1,3,5-hexatriene (DPH). All the compounds decreased the fluorescence polarization of DPH, and these decreases were proportional to the increase in Ca2+-ATPase produced by these drugs. These findings suggest that the increase in Ca2+-ATPase and calcium efflux produced by ethanol and pentobarbital results from the membrane-disordering effects of these drugs.