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Cinepazide maleate Sale

(Synonyms: 马来酸桂哌齐特; MD-67350) 目录号 : GC16161

Cinepazide Maleate (MD-67350) 是一种哌嗪衍生物,可作为弱钙通道阻滞剂。

Cinepazide maleate Chemical Structure

Cas No.:26328-04-1

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥357.00
现货
50mg
¥525.00
现货

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Sample solution is provided at 25 µL, 10mM.

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产品描述

Cinepazide Maleate is a vasodilator.Target: OthersCinepazide maleate is a maleate salt form of cinepazide which is a vasodilator. Cinepazide (30 mg/kg, i.v.) potentiated the vertebral vasodilator response of dogs to intravertebral adenosine and cyclic AMP, Intravertebral cinepazide(1-10 mg) increased vertebral blood flow in a dose-related manner and the effect was partially inhibited by intravenous pretreatment with aminophylline but not by pretreatment with autonomic antagonists. Cinepazide resembled cinnarizine and papaverine in that the drug antagonized rabbit aortic contraction induced by KCl, norepinephrine or CaCl2 [1]. Cinepazide in concentrations ranging from 10-6 to 10-5M augmented the relaxing responses to ATP, adenosine and cAMP. However, this agent did not affect the relaxations induced by isoproterenol and papaverine and the contractions induced by 5-HT, prostaglandin F2α and ATP. cinepazide selectively potentiates the relaxing response mediated through purinergic P1 receptors [2].

References:
[1]. Akashi, A., et al., [Cardiovascular pharmacology of cinepazide, a new cerebral vasodilator (author's transl)]. Nihon Yakurigaku Zasshi, 1979. 75(5): p. 507-16.
[2]. Muramatsu, I., et al., Effects of cinepazide on the purinergic responses in the dog cerebral artery. Pharmacology, 1984. 28(1): p. 27-33.

Chemical Properties

Cas No. 26328-04-1 SDF
别名 马来酸桂哌齐特; MD-67350
化学名 (Z)-but-2-enedioic acid;(E)-1-[4-(2-oxo-2-pyrrolidin-1-ylethyl)piperazin-1-yl]-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one
Canonical SMILES COC1=CC(=CC(=C1OC)OC)C=CC(=O)N2CCN(CC2)CC(=O)N3CCCC3.C(=CC(=O)O)C(=O)O
分子式 C22H31N3O5.C4H4O4 分子量 533.57
溶解度 ≥ 16.85mg/mL in DMSO 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 1.8742 mL 9.3708 mL 18.7417 mL
5 mM 0.3748 mL 1.8742 mL 3.7483 mL
10 mM 0.1874 mL 0.9371 mL 1.8742 mL
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