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Cichoric Acid Sale

(Synonyms: 菊苣酸,Dicaffeoyltartaric acid) 目录号 : GN10662

Extracted from Cichorium intybus L;Suitability:Methanol,DMSO;Store the product in sealed,cool and dry condition

Cichoric Acid Chemical Structure

Cas No.:70831-56-0,6537-80-0

规格 价格 库存 购买数量
20mg
¥1,082.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

L-Chicoric acid is an inhibitor of human immunodeficiency virus type 1 (HIV-1) integrase in vitro and of HIV-1 replication in tissue culture. IC50 value:Target:In vitro: Using quantitative real-time polymerase chain reaction (PCR), l-CA inhibits integration at concentrations from 500 nM to 10 μM but also inhibits entry at concentrations above 1 μM [1]. l-Chicoric acid, an inhibitor of human immunodeficiency virus type 1 (HIV-1) integrase, improves on the in vitro anti-HIV-1 effect of Zidovudine plus a protease inhibitor (AG1350) [2]. L-chicoric acid inhibits integrase and that the drug is likely to interact at residues near the catalytic triad in the integrase active site [3].In vivo:

References:
[1]. Ryan A Reinke, et al. l-Chicoric acid inhibits human immunodeficiency virus type 1 integration in vivo and is a noncompetitive but reversible inhibitor of HIV-1 integrase in vitro. VirologyVolume 326, Issue 2, 1 September 2004, Pages 203–219
[2]. W Edward Robinson Jr., et al. l-Chicoric acid, an inhibitor of human immunodeficiency virus type 1 (HIV-1) integrase, improves on the in vitro anti-HIV-1 effect of Zidovudine plus a protease inhibitor (AG1350). Antiviral ResearchVolume 39, Issue 2, August 1998, Pages 101–111
[3]. King PJ, et al. Resistance to the anti-human immunodeficiency virus type 1 compound L-chicoric acid results from a single mutation at amino acid 140 of integrase. Journal of Virology, 1998, 72(10): 8420-8424

Chemical Properties

Cas No. 70831-56-0,6537-80-0 SDF
别名 菊苣酸,Dicaffeoyltartaric acid
化学名 (2R,3R)-2,3-bis[[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy]butanedioic acid
Canonical SMILES C1=CC(=C(C=C1C=CC(=O)OC(C(C(=O)O)OC(=O)C=CC2=CC(=C(C=C2)O)O)C(=O)O)O)O
分子式 C22H18O12 分子量 474.37
溶解度 ≥ 50.3mg/mL in DMSO 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

制备储备液
1 mg 5 mg 10 mg
1 mM 2.1081 mL 10.5403 mL 21.0806 mL
5 mM 0.4216 mL 2.1081 mL 4.2161 mL
10 mM 0.2108 mL 1.054 mL 2.1081 mL
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