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Cetaben Sale

(Synonyms: 西他苯) 目录号 : GC16301

A non-fibrate hypolipidemic drug

Cetaben Chemical Structure

Cas No.:55986-43-1

规格 价格 库存 购买数量
5mg
¥491.00
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10mg
¥920.00
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50mg
¥3,854.00
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100mg
¥6,726.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

Cetaben is an unique PPARα-independent peroxisome proliferator.

The fibrate class of hypolipidemic drugs, such as fenofibrate and clofibrate, elicit their effects via binding to and activating peroxisome proliferator-activated receptor α (PPARα).

In vitro: Previous study showed that cetaben could cause little but reversible proliferation and morphological heterogeneity with the occurrence of dumbbell- and cup-shaped peroxisomal profiles. Peroxisomes in HepG2 cells showed marked variation in size and shape. Cetaben treatment of HepG2 cells was able to lead to disintegration of Golgi regions and augmented mitochondrial matrix [1].

In vivo: Animal study found that the changes in large scale of liver non-peroxisomal parameters were compared after 10 days administration of both cetaben and clofibric acid 200 mg/kg/day to male Wistar rats. No analogical changes were observed after cetaben treatment in the livers of experimental animals. It was also found that both drugs could increase the activities of alanine-glyoxylate aminotransferase-1 and acetylcarnitine transferase--enzymes with proven mitochondrial and peroxisomal location. Contrary to clofibric acid, cetaben did not increase solubilization of peroxisomal enzymes [2].

Clinical trial: So far, no clinical study has been conducted.

References:
[1] Kovacs, W. ,Walter, I., and Stangl, H. Cetaben-induced changes on the morphology and peroxisomal enzymes in MH1C1 rat hepatoma and HepG2 human hepatoblastoma cells. Histochemistry and Cell Biology 115, 509-519 (2001).
[2] Chandoga, J. ,Hampl, L.,Turecky, L., et al. Cetaben is an exceptional type of peroxisome proliferator. International Journal of Biochemistry 26(5), 679-696 (1994).

Chemical Properties

Cas No. 55986-43-1 SDF
别名 西他苯
化学名 4-(hexadecylamino)-benzoic acid
Canonical SMILES CCCCCCCCCCCCCCCCNC1=CC=C(C(O)=O)C=C1
分子式 C23H39NO2 分子量 361.6
溶解度 ≤1mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.7655 mL 13.8274 mL 27.6549 mL
5 mM 0.5531 mL 2.7655 mL 5.531 mL
10 mM 0.2765 mL 1.3827 mL 2.7655 mL
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