| CAY10444 目录号 GC18757 |
Sample solution is provided at 25 µL, 10mM.
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| Cas No. | 298186-80-8 | SDF | Download SDF |
| 别名 | N/A | ||
| 化学名 | 2-undecyl-thiazolidine-4-carboxylic acid | ||
| Canonical SMILES | [H]N1C(CCCCCCCCCCC)SC[C@H]1C(O)=O | ||
| 分子式 | C15H29NO2S | 分子量 | 287.5 |
| 溶解度 | 0.5mg/mL in DMF | 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. | ||
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
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A family of related G-protein coupled receptors that bind sphingosine-1 phosphate (S1P) as a high-affinity ligand have recently been cloned.[1],[2] S1P3/EDG3 is a member of this family that is widely expressed in many tissues, signaling via the ERK-½ and PLC/IP3 pathways. CAY10444 is a selective antagonist of S1P binding to the S1P3 receptor, blocking the calcium increase in HeLa cells by about 40% when present at 10 µM.[3]
Reference:
[1]. Kluk, M.J., and Hla, T. Signaling of sphingosine-1-phosphate via the S1P/EDG-family of G-protein-coupled receptors. Biochim. Biophys. Acta 1582(1-3), 72-80 (2002).
[2]. Chun, J., Goetzl, E.J., Hla, T., et al. International union of pharmacology. XXXIV. Lysophospholipid receptor nomenclature. Pharmacological Reviews 54, 265-269 (2002).
[3]. Koide, Y., Hasegawa, T., Takahashi, A., et al. Development of novel EDG3 antagonists using a 3D database search and their structure-activity relationships. Journal of Medicinal Chemistry 45, 4629-4638 (2002).