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Butenoyl PAF Sale

目录号 : GC11584

A PAF analog

Butenoyl PAF Chemical Structure

Cas No.:474944-25-7

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1mg
¥1,110.00
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5mg
¥4,949.00
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10mg
¥8,788.00
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50mg
¥38,386.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

Butenoyl PAF is a PAF receptor agonist [1].

Platelet activating factor (PAF), a phospholipid mediator of inflammation, is secreted by several cell types including arterial endothelial cells, and can activate polymorphonuclear leucocytes and monocytes via specific cell surface receptors. PAF also stimulates the production of active oxygen species by human monocyte - derived macrophages. PAF play important roles in a variety of pathophysiological states including acute allergy, inflammation, asthma, gastrointestinal ulceration, and toxic shock [1][2].

Butanoyl-PAF and Butenoyl PAF are both products of the oxidative decomposition of 2-arachidonoyl phospholipids. Although Butenoyl PAF is 10-fold less potent than PAF as a PAF receptor agonist and ligand, it is 100-fold more abundant in oxidized LDL than PAF. Therefore, oxidation products of LDL phospholipids were physiologically relevant bioactive PAF-like molecules [1].

References:
[1].  Marathe GK, Davies SS, Harrison KA, et al. Inflammatory platelet-activating factor-like phospholipids in oxidized low density lipoproteins are fragmented alkyl phosphatidylcholines. J Biol Chem. 1999 Oct 1;274(40):28395-404.
[2].  Davies SS, Pontsler AV, Marathe GK, et al. Oxidized alkyl phospholipids are specific, high affinity peroxisome proliferator-activated receptor gamma ligands and agonists. J Biol Chem. 2001 May 11;276(19):16015-23.

Chemical Properties

Cas No. 474944-25-7 SDF
化学名 1-O-hexadecyl-2-O-(2E-butenoyl)-sn-glyceryl-3-phosphocholine
Canonical SMILES O=C(/C=C/C)O[C@@H](COP([O-])(OCC[N+](C)(C)C)=O)COCCCCCCCCCCCCCCCC
分子式 C28H56NO7P 分子量 549.7
溶解度 DMF: 10 mg/ml,DMSO: .5 mg/ml,Ethanol: Miscible,PBS (pH 7.2): 5 mg/ml 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 1.8192 mL 9.0959 mL 18.1917 mL
5 mM 0.3638 mL 1.8192 mL 3.6383 mL
10 mM 0.1819 mL 0.9096 mL 1.8192 mL
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