Home>>Peptides>>Bradykinin 2-9 (Des-Arg1-bradykinin)

Bradykinin 2-9 (Des-Arg1-bradykinin) Sale

(Synonyms: Des-Arg1-bradykinin) 目录号 : GC34042

缓激肽 2-9 (Des-Arg1-bradykinin) 是一种氨基截短的缓激肽。

Bradykinin 2-9 (Des-Arg1-bradykinin) Chemical Structure

Cas No.:16875-11-9

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5mg
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10mg
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Sample solution is provided at 25 µL, 10mM.

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产品描述

Bradykinin (2-9) is an amino-truncated Bradykinin peptide. Bradykinin (2-9) is a metabolite of Bradykinin, cleaved by Aminopeptidase P.

The Bradykinin peptide system is a tissue-based system with potent cardiovascular and renal effects. To investigate the regulation of this system, a highly sensitive amino terminal-directed radioimmunoassay that, with high performance liquid chromatography, enables the measurement of Bradykinin-(1-7), Bradykinin-(1-8), and Bradykinin-(1-9), is developed. Together with a carboxy terminal-directed radioimmunoassay, Bradykinin peptides in rat kidney and blood are characterized. The predominant Bradykinin peptides in kidney are Bradykinin-(1-9) (~100 fmol/g wet weight of tissue) and Bradykinin-(1-7) (~70 fmol/g), with low levels of Bradykinin-(1-8) (~8 fmol/g) and Bradykinin-(4-9) (~12 fmol/g) detectable; Bradykinin-(2-9) and Bradykinin-(3-9) are below the limits of detection. In blood, the levels of Bradykinin-(1-9) are very low (~2 fmol/ml), and other Bradykinin peptides are below the limits ofdetection. Administration of the angiotensin converting enzyme (ACE) inhibitor Perindopril is associated with an approximate twofold increase in renal levels of Bradykinin-(1-8) and Bradykinin-(1-9) and a decrease in the Bradykinin-(1-7)/Bradykinin-(1-9) ratio. The amino terminal-directed radioimmunoassay is also applied to heart, aorta, brown adipose tissue, adrenal, lung, and brain. For these tissues, Bradykinin-(1-7) and Bradykinin-(1-9) are of similar abundance (16-340 fmol/g), with lower levels of Bradykinin-(1-8)[1].

[1]. Campbell DJ, et al. Bradykinin peptides in kidney, blood, and other tissues of the rat. Hypertension. 1993 Feb;21(2):155-65.

Chemical Properties

Cas No. 16875-11-9 SDF
别名 Des-Arg1-bradykinin
Canonical SMILES Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg
分子式 C44H61N11O10 分子量 904.02
溶解度 Soluble in DMSO 储存条件 Store at -20°C
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1 mM 1.1062 mL 5.5309 mL 11.0617 mL
5 mM 0.2212 mL 1.1062 mL 2.2123 mL
10 mM 0.1106 mL 0.5531 mL 1.1062 mL
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