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BODIPY-Cholesterol 目录号 GC42964

A fluorescently-tagged cholesterol

规格 价格 库存 购买数量
500μg
¥1,287.00
现货
1mg
¥2,444.00
现货
5mg
¥4,823.00
现货
10mg
¥9,009.00
现货

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Sample solution is provided at 25 µL, 10mM.

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Chemical Properties

Cas No. 878557-19-8 SDF Download SDF
别名 BCh2
化学名 (T-4)-[(3β)-24-(3,5-dimethyl-1H-pyrrol-2-yl-κN)-24-(3,5-dimethyl-2H-pyrrol-2-ylidene-κN)chol-5-en-3-olato]difluoro-boron
Canonical SMILES O[C@H](C1)CC[C@@]2(C)C1=CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]4([H])[C@H](C)CCC(C5=C(C)C=C(C)N5[B-]6(F)F)=C7[N+]6=C(C)C=C7C
分子式 C36H51BF2N2O 分子量 576.6
溶解度 0.5mg/ml in ethanol; 1mg/ml in DMSO, or in DMF 储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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产品描述

BODIPY-cholesterol is a biologically active and cell-permeable analog of cholesterol that is tagged with a fluorescent BODIPY group at carbon 24.[1],[2] It co-localizes with dehydroergosterol, a marker of cholesterol, in HeLa cells and is trafficked from the plasma membrane to the endocytic recycling compartment in BHK cells.2 BODIPY-cholesterol displays excitation/emission maxima of 480/508 nm, respectively, and has been used to monitor sterol uptake and inter-organelle sterol flux in cells. 

Reference:
1. Li, Z., Mintzer, E., and Bittman, R. First synthesis of free cholesterol-BODIPY conjugates. J. Org. Chem. 71(4), 1718-1721 (2006).
2. Wüstner, D., Solanko, L., Sokol, E., et al. Quantitative assessment of sterol traffic in living cells by dual labeling with dehydroergosterol and BODIPY-cholesterol. Chem. Phys. Lipids 164(3), 221-235 (2011).