Benzoin
(Synonyms: 安息香; DL-Benzoin; Desyl alcohol; (±)-2-Hydroxy-2-phenylacetophenone) 目录号 : GC61910
Benzoin 是从安息香科中分离得到的一种香树脂。Benzoin 可以作为植物的颜色添加剂。
Cas No.:119-53-9
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >97.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Benzoin is a kind of alsamic resin isolated from the styracaceae family. Benzoin can be used as a colour additive used for marking plants[1].
References:
[1]. COMPOUND SUMMARY. Benzoin
| Cas No. | 119-53-9 | SDF | |
| 别名 | 安息香; DL-Benzoin; Desyl alcohol; (±)-2-Hydroxy-2-phenylacetophenone | ||
| Canonical SMILES | OC(C1=CC=CC=C1)C(C2=CC=CC=C2)=O | ||
| 分子式 | C14H12O2 | 分子量 | 212.24 |
| 溶解度 | 储存条件 | Store at -20°C | |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 4.7116 mL | 23.5582 mL | 47.1165 mL |
| 5 mM | 0.9423 mL | 4.7116 mL | 9.4233 mL |
| 10 mM | 0.4712 mL | 2.3558 mL | 4.7116 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Advances in chemoselective intermolecular cross-benzoin-type condensation reactions
Org Biomol Chem 2017 Aug 23;15(33):6867-6887.PMID:28809427DOI:10.1039/c7ob01662j.
The intermolecular cross-benzoin and acyloin condensation reactions are powerful approaches to α-hydroxy carbonyls in a single step. However, their potentiality suffers from the occurrence of side reactions including self-condensation and the formation of the undesired cross-acyloin. The broad range of azolium salt precatalysts available confers high tunability to NHC mediated Benzoin condensation, assuring a good level of selectivity to the direct coupling between two non-equivalent aldehydes. Many efforts have also been devoted to the design of strategies that expand the range of suitable reaction partners beyond the traditional aldehydes and to the discovery of novel umpolung catalytic systems. The synthesis of both racemic and enantiomerically enriched acyloins is reviewed.
Recent advances in N-heterocyclic carbene (NHC)-catalysed Benzoin reactions
Beilstein J Org Chem 2016 Mar 9;12:444-61.PMID:27340440DOI:10.3762/bjoc.12.47.
N-Heterocyclic carbenes (NHCs) have emerged as a powerful class of organocatalysts that mediate a variety of organic transformations. The Benzoin reaction constitutes one of the earliest known carbon-carbon bond-forming reactions catalysed by NHCs. The rapid growth of NHC catalysis in general has resulted in the development of a variety of Benzoin and benzoin-type reactions. An overview of such NHC-catalysed Benzoin reactions is presented.
N-Heterocyclic carbene (NHC)-catalyzed intramolecular Benzoin condensation-oxidation
Org Biomol Chem 2021 Feb 25;19(7):1488-1492.PMID:33522549DOI:10.1039/d0ob02606a.
NHC-Catalyzed intramolecular Benzoin condensation-oxidation is developed for the expedient synthesis of diverse cyclic 1,2-diketones incorporated in dibenzo-fused seven-membered heterocycles in good to excellent yields, under ambient conditions. The presented carbene-catalyzed transformation appears to proceed through the Benzoin intermediate followed by aerobic oxidation.
The genetic toxicology of Benzoin and caprolactam
Mutat Res 1989 Nov;224(3):391-403.PMID:2682234DOI:10.1016/0165-1218(89)90187-0.
A summary is presented of the published literature on the genetic toxicology of the two rodent non-carcinogens Benzoin and caprolactam.
Phytochemical characterization of Styrax Benzoin resin extract, molecular docking, ADME, and antibacterial activity study
Nat Prod Res 2022 Oct 10;1-6.PMID:36214683DOI:10.1080/14786419.2022.2132244.
Styrax Benzoin fumes have a spiritual aspect from ancient times, magical essence like a pleasant perfume, and are employed in religious ceremonies in India. This study aims to identify the volatile compounds in S. Benzoin extract, their binding affinity to the bacterial target proteins, and study the antibacterial activity of the potential extract. The compounds obtained from GC-MS analysis of S. Benzoin extract were subjected to molecular docking studies against DHFR of Staphylococcus aureus, tRNA synthetase of Escherichia coli, DHPS of Mycobacterium tuberculosis. Molecular docking studies revealed that seventeen compounds out of 20 compounds exhibited higher binding affinity than co-ligand (-7.00 kcal/mol) against the Staphylococcus aureus enzyme DHFR. Consequently, the crude extracts were evaluated for antibacterial activity against S. aureus, and the acetone extract showed promising findings. S. Benzoin fumes might replace synthetic room fresheners, and promising compounds could be exploited in the cosmetics industry.