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Azumolene (sodium salt) Sale

(Synonyms: EU4093) 目录号 : GC42893

A muscle relaxant

Azumolene (sodium salt) Chemical Structure

Cas No.:105336-14-9

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1mg
¥496.00
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5mg
¥2,244.00
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10mg
¥3,975.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

Azumolene is a muscle relaxant that inhibits the release of calcium from skeletal muscle sarcoplasmic reticulum. It inhibits a component of store-operated calcium entry (SOCE) that is coupled to the skeletal muscle ryanodine receptor, with 20 µM azumolene causing a 70% reduction in SOCE in myotubes. Azumolene has utility in countering muscle dysfunction associated with malignant hyperthermia.

Chemical Properties

Cas No. 105336-14-9 SDF
别名 EU4093
Canonical SMILES BrC1=CC=C(C2=CN=C(/C=N/N3C([N-]C(C3)=O)=O)O2)C=C1.[Na+]
分子式 C13H8BrN4O3•Na 分子量 371.1
溶解度 DMF: 10 mg/ml,DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml,DMSO: 2 mg/ml 储存条件 Store at -20°C
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.6947 mL 13.4735 mL 26.9469 mL
5 mM 0.5389 mL 2.6947 mL 5.3894 mL
10 mM 0.2695 mL 1.3473 mL 2.6947 mL
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Research Update

The effect of Azumolene on hypercontractility and sarcoplasmic reticulum Ca(2+)-dependent ATPase activity of malignant hyperpyrexia-susceptible porcine skeletal muscle

Clin Exp Pharmacol Physiol 1991 Jul;18(7):489-95.PMID:1833102DOI:10.1111/j.1440-1681.1991.tb01482.x

1. Azumolene sodium is a new water-soluble derivative of dantrolene sodium that also acts as a skeletal-muscle relaxant. 2. Azumolene (6 mumol/L) inhibited the hypercontractility induced separately by 3% halothane, 2 mmol/L caffeine and 80 mmol/L potassium chloride in isolated malignant hyperpyrexia (MH)-susceptible muscle. Azumolene was equipotent with dantrolene in inhibiting the abnormal responses. 3. Like dantrolene, Azumolene (6 mumol/L) not only prevented but reversed the abnormal contractures induced by halothane and caffeine. Contracture responses to caffeine were also modified by Azumolene in control preparations. 4. In the presence of maximal effective concentrations of dantrolene, Azumolene failed to further relax caffeine-induced contractures, and the converse was also true. This was observed in both MH-susceptible and control preparations. 5. Sarcoplasmic reticulum Ca(2+)-dependent ATPase activity from MH-susceptible and control muscle was not affected by Azumolene. 6. Like dantrolene, Azumolene may inhibit Ca2+ release directly from the sarcoplasmic reticulum and be of therapeutic value for the treatment of MH.