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Atovaquone D4 Sale

(Synonyms: 阿托伐醌D4) 目录号 : GC38889

An internal standard for the quantification of atovaquone

Atovaquone D4 Chemical Structure

Cas No.:2070015-14-2

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1mg
¥3,150.00
现货
5mg
¥9,900.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

Atovaquone-d4 is intended for use as an internal standard for the quantification of atovaquone by GC- or LC-MS. Atovaquone is a broad-spectrum antiprotozoal agent that is active against Plasmodium, Toxoplasma, and Babesia, among other protozoa.1 It inhibits complex III activity on dihydroorotate in isolated P. falciparum and P. yoelii mitochondria more potently than in rat liver mitochondria (EC50s = 0.95, 0.94, and 510 nM, respectively) and depolarizes the mitochondrial membrane in P. yoelii-infected mouse erythrocytes (EC50 = 260 nM).2,3 Atovaquone also inhibits transport mediated by human breast cancer resistance protein (BCRP) and P-glycoprotein in membrane vesicles (IC50s = 0.23 and 6.8 μM, respectively).4 It inhibits the growth of T. gondii in MRC-5 human lung fibroblasts in vitro (IC50 = ~64 nM) and increases mean survival of T. gondii-infected mice from 5.5 to 21.2 days when administered at a dose of 100 mg/kg per day.5 Formulations containing atovaquone have been used in the treatment of Pneumocystis pneumonia and toxoplasmosis as well as in combination with proguanil in the treatment of malaria and babesiosis.

1.Kessl, J.J., Lange, B.B., Merbitz-Zahradnik, T., et al.Molecular basis for atovaquone binding to the cytochrome bc1 complexJ. Biol. Chem.278(33)31312-31318(2003) 2.Fry, M., and Pudney, M.Site of action of the antimalarial hydroxynaphthoquinone, 2-[trans-4-(4'-chlorophenyl) cyclohexyl]-3-hydroxy-1,4-naphthoquinone (566C80)Biochem. Pharmacol.43(7)1545-1553(1992) 3.Srivastava, I.K., Rottenberg, H., and Vaidya, A.B.Atovaquone, a broad spectrum antiparasitic drug, collapses mitochondrial membrane potential in a malarial parasiteJ. Biol. Chem.272(7)3961-3966(1997) 4.Rijpma, S.R., van den Heuvel, J.J., van der Velden, M., et al.Atovaquone and quinine anti-malarials inhibit ATP binding cassette transporter activityMalar. J.13359(2014) 5.Romand, S., Pudney, M., and Derouin, F.In vitro and in vivo activities of the hydroxynaphthoquinone atovaquone alone or combined with pyrimethamine, sulfadiazine, clarithromycin, or minocycline against Toxoplasma gondiiAntimicrob. Agents Chemother.37(11)2371-2378(1993)

Chemical Properties

Cas No. 2070015-14-2 SDF
别名 阿托伐醌D4
Canonical SMILES O=C1C2=C(C(C(O)=C1[C@@H]3CC[C@@H](C4=CC=C(Cl)C=C4)CC3)=O)C([2H])=C([2H])C([2H])=C2[2H]
分子式 C22H15D4ClO3 分子量 370.86
溶解度 Chloroform: soluble 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.6964 mL 13.4822 mL 26.9644 mL
5 mM 0.5393 mL 2.6964 mL 5.3929 mL
10 mM 0.2696 mL 1.3482 mL 2.6964 mL
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