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AR7 目录号 GC19035

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5mg
¥452.00
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10mg
¥756.00
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25mg
¥1,638.00
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50mg
¥2,867.00
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100mg
¥5,124.00
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Sample solution is provided at 25 µL, 10mM.

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Chemical Properties

Cas No. 80306-38-3 SDF Download SDF
别名 N/A
化学名 N/A
Canonical SMILES CC1=CC=C(C2=NC3=CC=C(Cl)C=C3OC2)C=C1
分子式 C15H12ClNO 分子量 257.71
溶解度 DMSO : 25 mg/mL (97.01 mM; Need ultrasonic);H2O : < 0.1 mg/mL (insoluble) 储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

产品描述

AR7 is a retinoic acid receptor α (RARα) antagonist.

Chaperone-mediated autophagy (CMA) contributes to cellular quality control and the cellular response to stress through the selective degradation of cytosolic proteins in lysosomes. Decrease in CMA activity occurs in aging and in age-related disorders. Signaling through the retinoic acid receptor alpha (RARα) inhibits CMA. AR7, an RARα antagonist, significantly activates CMA activity in mouse fibroblasts. A marked increase in CMA-activating potency is found when AR7 and GR1 are combined, supporting their cooperative effect. Treatment with the transcriptional repressor Actinomycin D partially reduces the stimulatory effect of AR7 on CMA, consistent with transcriptional changes contributing to the upregulation of CMA [1].

References:
[1]. Anguiano J, et al. Chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives. Nat Chem Biol. 2013 Jun;9(6):374-82.