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Aprepitant-d4 Sale

(Synonyms: 阿瑞匹坦-d4) 目录号 : GC46868

An internal standard for the quantification of aprepitant

Aprepitant-d4 Chemical Structure

Cas No.:1133387-60-6

规格 价格 库存 购买数量
500 μg
¥3,323.00
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1 mg
¥5,979.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

Aprepitant-d4 is intended for use as an internal standard for the quantification of aprepitant by GC- or LC-MS. Aprepitant an antiemetic compound and antagonist of the neurokinin-1 (NK1) receptor (Ki = 3 nM; IC50 = 0.09 nM for the human receptor).1,2 It is selective for NK1 over NK3 receptors (Ki = 454.1 nM for human NK3).1 In vivo, aprepitant (1 mg/kg) prevents plasma extravasation into the esophagus of guinea pigs induced by substance P .3 It also reduces NK1-agonist-induced foot tapping in gerbils. Formulations containing aprepitant have been used to prevent chemotherapy-induced nausea and vomiting.

1.Bissantz, C., Bohnert, C., Hoffmann, T., et al.Identification of a crucial amino acid in the helix position 6.51 of human tachykinin neurokinin 1 and 3 receptors contributing to the insurmountable mode of antagonism by dual NK1/NK3 antagonistsJ. Med. Chem.55(11)5061-5076(2012) 2.Finke, P.E., Meurer, L.C., Levorse, D.A., et al.Cyclopentane-based human NK1 antagonists. Part 1: Discovery and initial SARBioorg. Med. Chem. Lett.16(17)4497-4503(2006) 3.Meurer, L.C., Finke, P.E., Owens, K.A., et al.Cyclopentane-based human NK1 antagonists. Part 2: Development of potent, orally active, water-soluble derivativesBioorg. Med. Chem. Lett.16(17)4504-4511(2006)

Chemical Properties

Cas No. 1133387-60-6 SDF
别名 阿瑞匹坦-d4
Canonical SMILES C[C@@H](O[C@@H]1[C@H](C2=C([2H])C([2H])=C(F)C([2H])=C2[2H])N(CC3=NNC(N3)=O)CCO1)C4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4
分子式 C23H17D4F7N4O3 分子量 538.5
溶解度 DMF: 25 mg/ml,DMSO: 16 mg/ml,Ethanol: 3 mg/ml 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
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1 mM 1.857 mL 9.2851 mL 18.5701 mL
5 mM 0.3714 mL 1.857 mL 3.714 mL
10 mM 0.1857 mL 0.9285 mL 1.857 mL
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