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API-1 Sale

(Synonyms: NSC 177223) 目录号 : GC18374

An Akt inhibitor

API-1 Chemical Structure

Cas No.:36707-00-3

规格 价格 库存 购买数量
1mg
¥444.00
现货
5mg
¥1,951.00
现货
10mg
¥3,664.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

API-1 is an inhibitor of Akt that reduces the level of phosphorylated Akt (IC50 = ~0.8 uM in OVCAR3 cells) by binding to Akt and blocking its translocation to the cell membrane. It reduces cell proliferation in various cancer cell lines, induces apoptosis, and, at a dose of 10 mg/kg per day, decreases tumor growth in a mouse xenograft model. API-1 inhibition of Akt leads to proteasomal degradation of the downstream mediator Mcl-1. Likely independent of Akt binding, API-1 inhibits cell growth (IC50s = 2-5 uM) and induces apoptosis in non-small cell lung and head and neck squamous cancer (NSCLC and HNSCC) cell lines with concomitant increases in caspase-3, -8, and -9 cleavage. It reduces the levels of cellular FLICE-inhibitory protein (c-FLIP), an important regulator of apoptosis, through ubiquitin- and proteasome-mediated degradation. It also has a synergistic effect on apoptosis in combination with TRAIL/APO-2L.The information regarding the reduction in phosphorylated Akt levels, IC50 value, translocation, cell proliferation, and xenograft tumor growth was drawn from a paper that has been retracted; however, the information specified in the retraction statement has not been included.

Chemical Properties

Cas No. 36707-00-3 SDF
别名 NSC 177223
化学名 4-amino-5,8-dihydro-5-oxo-8-β-D-ribofuranosyl-pyrido[2,3-d]pyrimidine-6-carboxamide
Canonical SMILES O=C1C2=C(N)N=CN=C2N([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)C=C1C(N)=O
分子式 C13H15N5O6 分子量 337.3
溶解度 DMSO : 5.8 mg/mL (15.45 mM) 储存条件 Store at -20°C
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1 mg 5 mg 10 mg
1 mM 2.9647 mL 14.8236 mL 29.6472 mL
5 mM 0.5929 mL 2.9647 mL 5.9294 mL
10 mM 0.2965 mL 1.4824 mL 2.9647 mL
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