Home>>Signaling Pathways>> Endocrinology and Hormones>>Angiotensin 1/2 (5-7)
Angiotensin 1/2 (5-7) 目录号 GP10079

Vasoconstrictor

规格 价格 库存 购买数量
5mg
¥462.00
现货
10mg
¥693.00
现货
25mg
¥1,029.00
现货

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Sample solution is provided at 25 µL, 10mM.

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Chemical Properties

Cas No. N/A SDF
别名 H2N-Ile-His-Pro-OH
化学名 N/A
Canonical SMILES N[C@@H]([C@H](C)CC)C(N[C@@H](CC1=CNC=N1)C(N2CCC[C@@H]2C(O)=O)=O)=O
分子式 C17H27N5O4 分子量 365.43
溶解度 ≥ 36.5mg/mL in DMSO 储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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产品描述

Angiotensin 1/2 (5-7), (C17H27N5O4), a peptide with the sequence H2N-Ile-His-Pro-OH, MW=365.43. Angiotensin is a peptide hormone that causes vasoconstriction and a subsequent increase in blood pressure. Angiotensin is an oligopeptide and is a hormone and a powerful dipsogen. It is derived from the precursor molecule angiotensinogen, a serum globulin produced in the liver. It plays an important role in the renin-angiotensin system1. Angiotensin I is formed by the action of renin on angiotensinogen. Renin is produced in the kidneys in response to renal sympathetic activity, decreased intrarenal blood pressure at the juxtaglomerular cells2, or decreased delivery of Na+ and Cl- to the macula densa3.If less Na+ is sensed by the macula densa, renin release by juxtaglomerular cells is increased.Renin cleaves the peptide bond between the leucine (Leu) and valine (Val) residues on angiotensinogen, creating the ten-amino acid peptide (des-Asp) angiotensin I Angiotensin I appears to have no biological activity and exists solely as a precursor to angiotensin 2.

References:
1. Basso N, Terragno NA (December 2001). "History about the discovery of the renin-angiotensin system". Hypertension 38 (6): 1246–9.
2. Skurk T, Lee YM, Hauner H (May 2001). "Angiotensin II and its metabolites stimulate PAI-1 protein release from human adipocytes in primary culture". Hypertension 37 (5): 1336–40.
3. Williams GH, Dluhy RG (2008). "Chapter 336: Disorders of the Adrenal Cortex". In Loscalzo J, Fauci AS, Braunwald E, Kasper DL, Hauser SL, Longo DL. Harrison's principles of internal medicine. McGraw-Hill Medical.