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Amodiaquine-d10 Sale

(Synonyms: Camoquine-d10, Flavoquine-d10) 目录号 : GC45725

An internal standard for the quantification of amodiaquine

Amodiaquine-d10 Chemical Structure

Cas No.:1189449-70-4

规格 价格 库存 购买数量
1mg
¥3,854.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

Amodiaquine-d10 is intended for use as an internal standard for the quantification of amodiaquine by GC- or LC-MS. Amodiaquine is a prodrug form of the antimalarial compound N-desethyl amodiaquine .1,2 It is active against several strains of P. falciparum in vitro (EC50s = 0.23-0.52 nM) and exhibits a synergistic effect when used in combination with N-desethyl amodiaquine.1 Amodiaquine dose-dependently inhibits development of parasitemia in a mouse model of P. berghei infection.3

|1. Mariga, S.T., Gil, J.P., Sisowath, C., et al. Synergism between amodiaquine and its major metabolite, desethylamodiaquine, against Plasmodium falciparum in vitro. Antimicrob. Agents Chemother. 48(11), 4089-4096 (2004).|2. SÁ, J.M., Chong, J.L., and Wellems, T.E. Malaria drug resistance: New observations and developments. Essays Biochem. 51, 137-160 (2014).|3. Jacobs, R.L., Alling, D.W., and Cantrell, W.F. An evaluation of antimalarial combinations against Plasmodium berghei in the mouse. J. Parasitol. 49(6), 920-925 (1963).

Chemical Properties

Cas No. 1189449-70-4 SDF
别名 Camoquine-d10, Flavoquine-d10
Canonical SMILES OC(C=C1)=C(CN(C([2H])([2H])C([2H])([2H])[2H])C([2H])([2H])C([2H])([2H])[2H])C=C1NC2=CC=NC3=C2C=CC(Cl)=C3
分子式 C20H12ClD10N3O 分子量 365.9
溶解度 Chloroform: soluble,Methanol: soluble 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.733 mL 13.6649 mL 27.3299 mL
5 mM 0.5466 mL 2.733 mL 5.466 mL
10 mM 0.2733 mL 1.3665 mL 2.733 mL
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