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Alosetron Sale

(Synonyms: 阿洛司琼; GR 68755; GR 68755X) 目录号 : GC13654

A 5-HT3 receptor antagonist

Alosetron Chemical Structure

Cas No.:122852-42-0

规格 价格 库存 购买数量
50mg
¥1,092.00
现货
10mg
¥378.00
现货

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Sample solution is provided at 25 µL, 10mM.

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产品描述

Alosetron (GR 68755) is a Serotonin 5HT3-receptor antagonist that is used in treatment of irritable bowel syndrome.IC50 Value: Target: 5-HT ReceptorAlosetron has an antagonist action on the 5-HT3 receptors of the enteric nervous system of the gastrointestinal tract. While being a 5-HT3 antagonist like ondansetron, it is not classified or approved as an antiemetic. Since stimulation of 5-HT3 receptors is positively correlated with gastrointestinal motility, alosetron's 5-HT3 antagonism slows the movement of fecal matter through the large intestine, increasing the extent to which water is absorbed, and decreasing the moisture and volume of the remaining waste products. From Wikipedia.

References:
[1]. Alosetron: an effective treatment for diarrhea-predominant irritable bowel syndrome By Harris, Lucinda A.; Chang, Lin From Women's Health (2007), 3(1), 15-27.
[2]. Cremonini F, Nicandro JP, Atkinson V, Shringarpure R, Chuang E, Lembo A.Randomised clinical trial: alosetron improves quality of life and reduces restriction of daily activities in women with severe diarrhoea-predominant IBS.Aliment Pharmacol Ther. 2012 Sep;36(5):437-48. doi: 10.1111/j.1365-2036.2012.05208.x.
[3]. Lucak S.Irritable bowel syndrome and ischemic colitis: evidence supporting the increased use of alosetron.Therap Adv Gastroenterol. 2012 Jul;5(4):215-8.
[4]. Nicandro JP, Shin P, Chuang E.Evaluation of treatment continuation with alosetron by IBS-D severity criteria.Curr Med Res Opin. 2012 Mar;28(3):449-56.

Chemical Properties

Cas No. 122852-42-0 SDF
别名 阿洛司琼; GR 68755; GR 68755X
化学名 5-methyl-2-((5-methyl-1H-imidazol-4-yl)methyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-1-one
Canonical SMILES CC1=C(N=CN1)CN2CCC3=C(C2=O)C4=CC=CC=C4N3C
分子式 C17H18N4O 分子量 294.35
溶解度 15mg/ml in Water 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 3.3973 mL 16.9866 mL 33.9732 mL
5 mM 0.6795 mL 3.3973 mL 6.7946 mL
10 mM 0.3397 mL 1.6987 mL 3.3973 mL
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