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AEG 3482 Sale

(Synonyms: 6-苯基咪唑并[2,1-B]-1,3,4-噻二唑-2-磺酰胺) 目录号 : GC10204

An inhibitor of p75NTR- and NRAGE-induced apoptosis

AEG 3482 Chemical Structure

Cas No.:63735-71-7

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥546.00
现货
10mg
¥872.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

Quality Control & SDS

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实验参考方法

Cell experiment [1]:

Cell lines

PC12 neuronal cells

Preparation method

The solubility of this compound in DMSO is > 14 mg/mL. General tips for obtaining a higher concentration: Please warm the tube at 37 ℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months.

Reacting condition

10, 20 and 40 µM, 18 h

Applications

AEG 3482 is a potent antiapoptotic compound. In PC12 neuronal cells AEG 3482 inhibited proapoptotic JNK activity and blocked p75NTR- and NRAGE-induced apoptosis. AEG 3482 inhibited the JNK pathway through increasing HSP70 expression.

References:

[1]. Salehi A H, Morris S J, Ho W C, et al. AEG3482 is an antiapoptotic compound that inhibits Jun kinase activity and cell death through induced expression of heat shock protein 70[J]. Chemistry & biology, 2006, 13(2): 213-223.

产品描述

AEG3482 is a small-molecule inhibitor of Jun kinase (JNK)-dependent apoptosis. [1,2]

Jun kinases, also called Jun N-terminal kinase stress-activated protein kinases. Activation of the JNK signaling pathway is a major event in neuronal apoptosis. This is proved by pathological specimens from Alzheimer’s disease, as well as samples from mouse models of Alzheimer’s and Huntington’s disease, reveal activated JNK. [2]

AEG3482 blocks apoptosis induced by the p75 neurotrophin receptor (p75NTR) or NRAGE, which is p75NTR’s cytosolic interactor,. AEG3482 inhibits proapoptotic JNK activity. AEG3482 induces production of heat shock protein 70 (HSP70) which is an endogenous inhibitor of JNK. HSP70 accumulation is required for the AEG3482-induced JNK blockade. [1]

As described, activation of C-jun N-terminal kinase (JNK) signaling is associated with neuronal cell death. AEG3482 interacts with heat shock protein 90 leading to inhibition of JNK and blockade of neuronal apoptosis. So AEG3482 can serve as useful tools for basic research, and it may have therapeutic potential for the treatment of acute and chronic neurological disorders. In the neuropathologicalstate, the chaperone-mediated stress response may be primed for response to Hsp90 inhibitors; and AEG3482, may be selective neuroprotective agents.[1,2]

References:
[1]Salehi AH, Morris SJ, Ho WC, etal. , AEG3482 is an antiapoptotic compound that inhibits Jun kinase activity and cell death through induced expression of heat shock protein 70. Chem Biol. 2006 Feb;13(2):213-23.
[2] Gallo KA.   Targeting HSP90 to halt neurodegeneration. Chem Biol. 2006 Feb;13(2):115-6.

Chemical Properties

Cas No. 63735-71-7 SDF
别名 6-苯基咪唑并[2,1-B]-1,3,4-噻二唑-2-磺酰胺
化学名 6-phenylimidazo[2,1-b][1,3,4]thiadiazole-2-sulfonamide
Canonical SMILES NS(C1=NN(C(S1)=N2)C=C2C3=CC=CC=C3)(=O)=O
分子式 C10H8N4O2S2 分子量 280.33
溶解度 ≥ 14mg/mL in DMSO 储存条件 Store at RT
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mM 3.5672 mL 17.8361 mL 35.6722 mL
5 mM 0.7134 mL 3.5672 mL 7.1344 mL
10 mM 0.3567 mL 1.7836 mL 3.5672 mL
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