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Acetyl Angiotensinogen (1-14), porcine 目录号 GP10059

Angiotensinogen precursor

规格 价格 库存 购买数量
5mg
¥315.00
现货
10mg
¥536.00
现货
25mg
¥767.00
现货

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Sample solution is provided at 25 µL, 10mM.

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Chemical Properties

Cas No. 66641-26-7 SDF
别名 Ac-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Leu-Val-Tyr-Ser-OH
化学名 N/A
Canonical SMILES CCC(C)C(C(=O)NC(CC1=CN=CN1)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)NC(CC4=CN=CN4)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NC(CC5=CC=C(C=C5)O)C(=O)NC(CO)C(=O)O)NC(=O)C(CC6=CC=C(C=C6)O)NC(=O)C(C(C)C)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC(=O)O)NC(=O)C
分子式 C87H125N21O21 分子量 1801.05
溶解度 ≥ 180.1mg/mL in DMSO 储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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产品描述

Acetyl Angiotensinogen (1-14),porcine, (C87H125N21O21) is a peptide with the sequence AC-ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS-LEU-LEU-VAL-TYR-SER-OH, MW= 1801.05. The protein encoded by the Angiotensinogen gene is known as pre-angiotensinogen or angiotensinogen precursor. Pre-angiotensinogen is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure1. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. Angiotensin II is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia2. Mutations in the gene are associated with susceptibility to essential hypertension and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in the gene have also been associated with non-familial structural atrial fibrillation and inflammatory bowel disease.

References:
1. Basso N, Terragno NA (December 2001). "History about the discovery of the renin-angiotensin system". Hypertension 38 (6): 1246–9.
2. Skurk T, Lee YM, Hauner H (May 2001). "Angiotensin II and its metabolites stimulate PAI-1 protein release from human adipocytes in primary culture". Hypertension 37 (5): 1336–40.