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A-3 hydrochloride 目录号 GC60037

规格 价格 库存 购买数量
10mM*1 mL in DMSO
¥1,188.00
现货
10mg
¥1,080.00
现货
50mg
¥3,150.00
现货
100mg
¥5,040.00
现货

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Sample solution is provided at 25 µL, 10mM.

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Chemical Properties

Cas No. 78957-85-4 SDF Download SDF
别名 N/A
化学名 N/A
Canonical SMILES O=S(C1=C2C=CC=C(Cl)C2=CC=C1)(NCCN)=O.[H]Cl
分子式 C12H14Cl2N2O2S 分子量 321.22
溶解度 DMSO: 125 mg/mL (389.14 mM) 储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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产品描述

A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. It against PKA (Ki=4.3 µM), casein kinase II (Ki=5.1 µM) and myosin light chain kinase (MLCK) (Ki=7.4 µM). A-3 hydrochloride also inhibits PKC and casein kinase I with Ki values of 47 µM and 80 µM, respectively[1].

A-3 hydrochloride inhibits MLC-kinase competitively with respect to ATP and that the Ki value is 7.4 μM. A-3 is also a competitive inhibitor of cAMP-dependent protein kinase, cGMP-dependent protein kinase, protein kinase C, casein kinase I, and casein kinase II, with respect to ATP, exhibits Ki values of 4.3 μM, 3.8 μM, 47 μM, 80 μM, and 5.1 μM, respectively[1].

[1]. Inagaki M, et al. Naphthalenesulfonamides as calmodulin antagonists and protein kinase inhibitors. Mol Pharmacol. 1986 Jun;29(6):577-81.