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β-Carboline-1-carboxylic Acid Sale

(Synonyms: 1-Formic Acid-β-carboline) 目录号 : GC48920

An alkaloid with diverse biological activities

β-Carboline-1-carboxylic Acid Chemical Structure

Cas No.:26052-96-0

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1mg
¥3,683.00
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5mg
¥12,900.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

β-Carboline-1-carboxylic acid is an alkaloid that has been found in P. quassioides and has diverse biological activities.1,2,3 It reduces LPS-induced increases in MCP-1, TNF-α, IL-6, and IL-1β levels in RAW 264.7 cells when used at a concentration of 15 µg/ml and inhibits the epithelial-to-mesenchymal transition (EMT) induced by TGF-β1 in A549 cells.2 β-Carboline-1-carboxylic acid induces cytotoxicity in CT26.WT, K562, and SGC-7901 cells (IC50s = 14.96, 22.11, and 19.7 µg/ml, respectively) but not HepG2 or A549 cells (IC50s = 36.41 and 41.51 µg/ml, respectively).1 It also inhibits cAMP phosphodiesterase with an IC50 value of 96 µM.3

1.Lai, Z.-Q., Liu, W.-H., Ip, S.-P., et al.Seven alkaloids from Picrasma quassioides and their cytotoxic activitiesChem. Nat. Compd.50(5)884-888(2014) 2.Cui, Y., Jiang, L., Yu, R., et al.β-carboline alkaloids attenuate bleomycin induced pulmonary fibrosis in mice through inhibiting NF-kb/p65 phosphorylation and epithelial-mesenchymal transitionJ. Ethnopharmacol.243112096(2019) 3.Sung, Y.-I., Koike, K., Nikaido, T., et al.Inhibitors of cyclic AMP phosphodiesterase in Picrasma quassioides BENNET, and inhibitory activities of related β-carboline alkaloidsChem. Pharm. Bull. (Tokyo)32(5)1872-1877(1984)

Chemical Properties

Cas No. 26052-96-0 SDF
别名 1-Formic Acid-β-carboline
Canonical SMILES O=C(C1=NC=CC2=C1NC3=C2C=CC=C3)O
分子式 C12H8N2O2 分子量 212.2
溶解度 储存条件 -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 4.7125 mL 23.5627 mL 47.1254 mL
5 mM 0.9425 mL 4.7125 mL 9.4251 mL
10 mM 0.4713 mL 2.3563 mL 4.7125 mL
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