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α-Synuclein (61-75) (TFA) Sale

目录号 : GC63271

α-Synuclein (61-75) TFA 是 α-Synuclein 的 61-75 片段。α-Synuclein 是一种丰富的神经元蛋白,在突触前神经末梢高度丰富。α-Synuclein 是一种帕金森氏病 (PD) 的生物标志物。

α-Synuclein (61-75) (TFA) Chemical Structure

规格 价格 库存 购买数量
1 mg
¥720.00
现货
5 mg
¥2,160.00
现货
10 mg
¥3,420.00
现货
25 mg
¥6,840.00
现货

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Sample solution is provided at 25 µL, 10mM.

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产品描述

α-Synuclein (61-75) TFA is the 61-75 fragment of α-Synuclein. α-Synuclein is an abundant neuronal protein that is highly enriched in presynaptic nerve terminals. α-Synuclein is a potential biomarker for Parkinson’s disease (PD)[1][2].

Lewy bodies containing α-synuclein are a neuropathological hallmark of PD, and missense mutations in α-Synuclein (A30P, E46K, H50Q, G51D, A53E, A53T), as well as α-Synuclein gene duplications and triplications, appear to cause PD. Moreover, polymorphisms in regulatory elements of the α-Synuclein gene predispose individuals to PD and are linked to an early onset of the disease. The non-Aβ-amyloid component (NAC) region of α-synuclein is relatively hydrophobic and aggregation-prone in human α-Synuclein but not in mouse α-Synuclein nor in the corresponding homologous region of human β-synuclein. Yet, β-synuclein is more homologous to α-Synuclein in the N-terminal sequences (74%) than γ-synuclein (67%)[1].

[1]. Jacqueline BurrÉ, et al. Cell Biology and Pathophysiology of α-Synuclein. Cold Spring Harb Perspect Med. 2018 Mar 1;8(3):a024091.
[2]. Nelson Ferreira, et al. Trans-synaptic spreading of alpha-synuclein pathology through sensory afferents leads to sensory nerve degeneration and neuropathic pain. Acta Neuropathol Commun. 2021 Feb 25;9(1):31.

Chemical Properties

Cas No. SDF
分子式 C62H104F3N17O25 分子量 1544.58
溶解度 DMSO : 100 mg/mL (64.74 mM; Need ultrasonic) 储存条件 -20°C, away from moisture
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 0.6474 mL 3.2371 mL 6.4743 mL
5 mM 0.1295 mL 0.6474 mL 1.2949 mL
10 mM 0.0647 mL 0.3237 mL 0.6474 mL
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