Home>>Lipids>> Cyclooxygenase>>8-iso Prostaglandin A1

8-iso Prostaglandin A1

(Synonyms: 8-epi PGA1, 8-iso PGA1) 目录号 : GC41138

An isoprostane

8-iso Prostaglandin A1 Chemical Structure

Cas No.:211186-29-7

规格 价格 库存 购买数量
100μg
¥428.00
现货
500μg
¥1,388.00
现货
1mg
¥2,365.00
现货

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Sample solution is provided at 25 µL, 10mM.

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Quality Control & SDS

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产品描述

8-iso Prostaglandin A1 (8-iso PGA1) is an isoprostane and a member in a large family of prostanoids of non-cyclooxygenase origin. It occurs as a common minor impurity in most commercial preparations of PGE1. The biological activity of 8-iso PGA1 has not been studied in depth or reported in the literature.

Chemical Properties

Cas No. 211186-29-7 SDF
别名 8-epi PGA1, 8-iso PGA1
Canonical SMILES CCCCCC(O)/C=C/[C@H]1C=CC(=O)[C@H]1CCCCCCC(=O)O
分子式 C20H32O4 分子量 336.5
溶解度 DMF: >75 mg/ml (from PGA1),DMSO: >50 mg/ml (from PGA1),Ethanol: >100 mg/ml (from PGA1),PBS pH 7.2: >2.4 mg/ml (from PGA1) 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.9718 mL 14.8588 mL 29.7177 mL
5 mM 0.5944 mL 2.9718 mL 5.9435 mL
10 mM 0.2972 mL 1.4859 mL 2.9718 mL
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Research Update

Crystal structure of Arabidopsis thaliana 12-oxophytodienoate reductase isoform 3 in complex with 8-iso prostaglandin A(1)

Proteins 2011 Nov;79(11):3236-41.PMID:21915915DOI:10.1002/prot.23153.

12-Oxophytodienoate reductase 3 (OPR3), one of the enzymes involved in the biosynthesis of the plant hormone jasmonic acid (JA), catalyzes the reduction of the cyclopentenone ring of (9S,13S)-12-oxophytodienoate [(9S,13S)-OPDA]. However, there has been no structural information about the interaction between OPRs and the physiologically relevant (9S,13S)-OPDA. Here we report the crystal structure of Arabidopsis thaliana OPR3 in complex with 8-iso Prostaglandin A1 (8-iso PGA1) which has the same stereochemistry in the cyclopentenone ring as in the physiologically relevant 9S,13S-OPDA. This structure reveals a new binding mode for substrate that likely contributes to the relaxed stereospecificity observed for AtOPR3.