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7-keto Dehydroepiandrosterone Sale

(Synonyms: 7-酮基去氢表雄酮) 目录号 : GC40475

An Analytical Reference Standard

7-keto Dehydroepiandrosterone Chemical Structure

Cas No.:566-19-8

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5mg
¥599.00
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10mg
¥1,079.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

7-keto Dehydroepiandrosterone is an analytical reference standard categorized as a steroid metabolite of dehydroepiandrosterone . 7-keto Dehydroepiandrosterone reduces ethanol consumption without the hormone-generating effects of dehydroepiandrosterone in rats. This product is intended for research and forensic applications.

Chemical Properties

Cas No. 566-19-8 SDF
别名 7-酮基去氢表雄酮
Canonical SMILES O[C@H](C1)CC[C@@]2(C)C1=CC([C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CCC4=O)=O
分子式 C19H26O3 分子量 302.4
溶解度 DMF: 25 mg/ml,DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml,DMSO: 15 mg/ml,Ethanol: 10 mg/ml 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 3.3069 mL 16.5344 mL 33.0688 mL
5 mM 0.6614 mL 3.3069 mL 6.6138 mL
10 mM 0.3307 mL 1.6534 mL 3.3069 mL
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Research Update

Effects of 7-keto Dehydroepiandrosterone on voluntary ethanol intake in male rats

Alcohol 2011 Jun;45(4):349-54.PMID:21051179DOI:10.1016/j.alcohol.2010.08.020.

Administration of dehydroepiandrosterone (DHEA), a neurosteroid that can negatively modulate the GABA A receptor, has been shown to decrease voluntary intake of ethanol in rats. In vivo, DHEA can be metabolized to a variety of metabolites, including 3β-acetoxyandrost-5-ene-7,17-dione (7-keto DHEA), a metabolite without the prohormonal effects of DHEA. This study compared the effectiveness of 7-keto DHEA with DHEA for reducing ethanol intake in the same group of rats. The subjects, previously trained to drink ethanol using a saccharin-fading procedure, had access to ethanol for 30 min daily and the amount consumed was recorded. Subjects were administered 10 and 56 mg/kg of DHEA or 7-keto DHEA intraperitoneally 15 min before drinking sessions. Subjects received each particular dose daily until one of two criteria was met, that is, either ethanol intake did not differ by more than 20% of the mean for 3 consecutive days or for a maximum of 8 days. Both 10 and 56 mg/kg of 7-keto DHEA significantly reduced the dose of ethanol consumed. Although 10mg/kg of 7-keto DHEA produced decreases similar to those found with DHEA, the 56-mg/kg dose of 7-keto DHEA was significantly more effective at decreasing the dose of ethanol consumed than the same dose of DHEA. These results show that 7-keto DHEA is comparable with, or possibly more effective than, DHEA at decreasing ethanol consumption in rats, and that 7-keto DHEA is a compound deserving further investigation as a possible clinical treatment for alcohol abuse without the prohormonal effects of DHEA.

A comparison of dehydroepiandrosterone and 7-keto Dehydroepiandrosterone with other drugs that modulate ethanol intake in rats responding under a multiple schedule

Behav Pharmacol 2012 Jun;23(3):250-61.PMID:22473025DOI:10.1097/FBP.0b013e32835342d2.

Dehydroepiandrosterone (DHEA), 7-keto DHEA, and several comparison drugs (ethanol, chlordiazepoxide, rauwolscine, and RO15-4513) were administered to male rats responding under a multiple schedule of food and ethanol presentation to determine their selectivity for decreasing ethanol-maintained responding. DHEA and 7-keto DHEA significantly decreased both ethanol-maintained and food-maintained responding, compared with the control, while also decreasing the blood ethanol concentration (BEC). Acute ethanol administration also decreased responding for both food and ethanol; however, ethanol-maintained responding was more potently decreased than food-maintained responding. BEC remained relatively stable after increasing ethanol doses. Among the other drugs tested, RO15-4513 was the most selective for decreasing ethanol-maintained responding compared with food-maintained responding, and it decreased BECs as ethanol-maintained responding decreased. The largest dose of rauwolscine significantly decreased responding for food, whereas it did not affect ethanol-maintained responding compared with the control. Low to intermediate doses of rauwolscine produced small, nonsignificant increases in ethanol-maintained responding and BECs. Chlordiazepoxide produced significant decreases in food-maintained responding and the dose of ethanol presented, but only at the highest dose tested. Although DHEA and 7-keto DHEA did not decrease ethanol-maintained responding as selectively as ethanol or RO15-4513 under the multiple schedule, these neurosteroids may be valuable pharmacological tools in the development of new treatments for alcohol abuse and dependence.