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5-Aminovaleric acid hydrochloride Sale

(Synonyms: 5-氨基戊酸) 目录号 : GC12713

5-氨基戊酸盐酸盐被认为是 γ-氨基丁酸 (GABA) 的亚甲基同系物,并作为弱 GABA 激动剂发挥作用。

5-Aminovaleric acid hydrochloride Chemical Structure

Cas No.:660-88-8

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5g
¥336.00
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25g
¥956.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

5-Aminovaleric acid has been identified as an important five-carbon platform chemical, which can be used for the synthesis of polymers and other chemicals of industrial interest as well.

In vitro: 5-Aminovaleric acid, a GABA analog, was reported to be able to inhibit GABA uptake, inactivate GABA aminotransferase, and could also both agonize and antagonize GABAb receptors. In addition, 5-aminovaleric acid has been found to be able to increase glutamine concentrations, thus possibly compensating for the decreased concentration of brain glutamine [1].

In vivo: Animal study found that 5-aminovaleric acid-treated rats showed a 3.5-fold reduction in the number of seizures than PBS-treated rats. In addition, both groups showed similar seizure frequency (~1 seizure/day). However, the fraction of the most severe type of seizures increased over time in the PBS treated group, but not in the 5-aminovaleric acid treated group. Moreover, 5-aminovaleric acid treated rats experienced a 2.3- and 2.6-fold lower fraction of stage 4 and 5 seizures than PBS-treated rats [1].

Clinical trial: Aminocaproic acid has been approved by FDA for the treatment of acute bleeding caused by elevated fibrinolytic activity. It has also been used for the prevention of recurrent hemorrhage in patients with traumatic hyphema [https://en.wikipedia.org/wiki/Aminocaproic_acid].

Reference:
[1] Dhaher R,Damisah EC,Wang H,Gruenbaum SE,Ong C,Zaveri HP,Gruenbaum BF,Eid T.  5-aminovaleric acid suppresses the development of severe seizures in the methionine sulfoximine model of mesial temporal lobe epilepsy. Neurobiol Dis.2014 Jul;67:18-23.

Chemical Properties

Cas No. 660-88-8 SDF
别名 5-氨基戊酸
化学名 5-aminopentanoic acid
Canonical SMILES O=C(O)CCCCN
分子式 C5H11NO2 分子量 117.15
溶解度 Soluble in DMSO 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 8.5361 mL 42.6803 mL 85.3606 mL
5 mM 1.7072 mL 8.5361 mL 17.0721 mL
10 mM 0.8536 mL 4.268 mL 8.5361 mL
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