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4-hydroxy Nonenal 目录号 GC42410

A lipid peroxidation product

规格 价格 库存 购买数量
1mg
¥767.00
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5mg
¥3,068.00
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10mg
¥5,369.00
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50mg
¥23,010.00
现货

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Sample solution is provided at 25 µL, 10mM.

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Chemical Properties

Cas No. 75899-68-2 SDF Download SDF
别名 4-HNE
化学名 (±)-4-hydroxy-2E-nonenal
Canonical SMILES CCCCCC(O)\C=C\C=O
分子式 C9H16O2 分子量 156.2
溶解度 50mg/mL in DMSO or DMF 储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

产品描述

4-hydroxy Nonenal is a lipid peroxidation product derived from oxidized ω-6 polyunsaturated fatty acids such as arachidonic acid.[1],[2] 4-hydroxy Nonenal is widely used as a marker of lipid peroxidation.[2] It exhibits various biological activities such as cytotoxicity, growth inhibiting activity, genotoxicity, and chemotactic activity.[1],[2],[3] 4-hydroxy Nonenal inhibits pro-oxidant-induced Ca2+ release from mitochondria at 10-50 µM.[2]

Reference:
[1]. Pryor, W.A., and Porter, N.A. Suggested mechanisms for the production of 4-hydroxy-2-nonenal from the autoxidation of polyunsaturated fatty acids Free Radical Biology & Medicine 8, 541-543 (1990).
[2]. Esterbauer, H., Schaur, R.J., and Zoliner, H. Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde, and related aldehydes Free Radical Biology & Medicine 11, 81-128 (1991).
[3]. Sodum, R.S., and Chung, F.L. 1,N2-ethenodeoxyguanosine as a potential marker for DNA adduct formation by trans-4-hydroxy-2-nonenal Cancer Research 48, 320-323 (1988).