|4-hydroperoxy Cyclophosphamide 目录号 GC42401|
Sample solution is provided at 25 µL, 10mM.
|Cas No.||39800-16-3||SDF||Download SDF|
|溶解度||30mg/mL in DMSO,Souble in chloroform and dichloromethane. Prepare for immediate use. Do not store after dissloved||储存条件||Store at -80°C, protect from light, stored under nitrogen|
|General tips||For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.|
|Shipping Condition||Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
4-hydroperoxy Cyclophosphamide (4-OOH-CY) is the active metabolite form of the prodrug Cyclophosphamide. 4-OOH-CY crosslinks DNA and induces T cell apoptosis independent of death receptor activation, but activates mitochondrial death pathways through production of reactive oxygen species (ROS). Formulations containing the prodrug Cyclophosphamide are used to treat lymphomas and autoimmune disorders.,
. Strauss, G., Westhoff, M.-A., Fischer-Posovszky, P., et al. 4-hydroperoxy-cyclophosphamide mediates caspase-independent T-cell apoptosis involving oxidative stress-induced nuclear relocation of mitochondrial apoptogenic factors AIF and EndoG. Cell Death Differ. 15(2), 332-343 (2008).
. Ahmed, A.R., and Hombal, S.M. Cyclophosphamide (Cytoxan). A review on relevant pharmacology and clinical uses. J. Am. Acad. Dermatol. 11(6), 1115-1126 (1984).
. Appel, G.B. New and future therapies for lupus nephritis. Cleve. Clin. J. Med. 79(2), 134-140 (2012).