3-hydroxy-3-methylglutaryl-Coenzyme A-d3 (ammonium salt)
(Synonyms: DL-3-hydroxy-3-methylglutaryl-CoA-d3, HMG-CoA-d3, Hydroxymethylglutaryl-CoA-d3) 目录号 : GC46599
A neuropeptide with diverse biological activities
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
3-hydroxy-3-methylglutaryl-Coenzyme A-d3 is intended for use as an internal standard for the quantification of 3-hydroxy-3-methylglutaryl-coenzyme A by GC- or LC-MS. 3-hydroxy-3-methylglutaryl-Coenzyme A (HMG-CoA) is an intermediate in several metabolic pathways.1,2,3,4 Conversion of HMG-CoA to mevalonate by HMG-CoA reductase is the rate-limiting first step in the cholesterol biosynthetic pathway.3,2 Alternatively, HMG-CoA can be cleaved into acetyl-CoA and the ketone body acetoacetate in mitochondria by HMG-CoA lyase.4,1 HMG-CoA is also an intermediate in the degradation of leucine.4
1.Laffel, L.Ketone bodies: A review of physiology, pathophysiology and application of monitoring to diabetesDiabetes Metab. Res. Rev.15(6)412-426(1999) 2.Espenshade, P.J., and Hughes, A.L.Regulation of sterol synthesis in eukaryotesAnnu. Rev. Genet.41401-427(2007) 3.Honda, A., Salen, G., Nguyen, L.B., et al.Regulation of early cholesterol biosynthesis in rat liver: Effects of sterols, bile acids, lovastatin, and BM 15.766 on 3-hydroxy-3-methylglutaryl coenzyme A synthase and acetoacetyl coenzyme A thiolase activitiesHepatology27(1)154-159(1998) 4.Berg, J.M., Tymoczko, J.L., and Stryer, L.Section 25.5 NAD+, FAD, and coenzyme A are formed from ATPBiochemistry5th Edition(2002)
| Cas No. | N/A | SDF | |
| 别名 | DL-3-hydroxy-3-methylglutaryl-CoA-d3, HMG-CoA-d3, Hydroxymethylglutaryl-CoA-d3 | ||
| Canonical SMILES | O[C@@H]1[C@H](OP([O-])([O-])=O)[C@@H](COP(OP(OCC(C)(C)[C@](O)([H])C(NCCC(NCCSC(CC(O)(C([2H])([2H])[2H])CC(O)=O)=O)=O)=O)([O-])=O)([O-])=O)O[C@H]1N2C3=C(C(N)=NC=N3)N=C2.[NH4+].[NH4+].[NH4+].[NH4+] | ||
| 分子式 | C27H37D3N7O20P3S.4NH4 | 分子量 | 982.8 |
| 溶解度 | Water: 50 mg/ml | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.0175 mL | 5.0875 mL | 10.175 mL |
| 5 mM | 0.2035 mL | 1.0175 mL | 2.035 mL |
| 10 mM | 0.1018 mL | 0.5088 mL | 1.0175 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。