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3,3',5'-Triiodo-L-thyronine Sale

(Synonyms: 碘塞罗宁,Reverse T3,rT3,3,3’,5’-T3) 目录号 : GC10384

A thyroid hormone variant

3,3',5'-Triiodo-L-thyronine Chemical Structure

Cas No.:5817-39-0

规格 价格 库存 购买数量
5mg
¥1,050.00
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10mg
¥1,800.00
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50mg
¥5,700.00
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100mg
¥9,900.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

3,3',5'-triiodo-L-thyronine (reverse T3 or rT3) and 3,5,3'-triiodo-L-thyronine (T3) are the metabolism of thyroxine (T4) [1]. 3,3',5'-Triiodo-L-thyronine is thyroid hormone receptors TRα and TRβ antagonist [1].

Thyroid hormones play important roles in the development of the mammalian brain by acting on migration and differentiation of neural cells, synaptogenesis, and myelination. The actions of thyroid hormones are mediated by nuclear thyroid hormone receptors (TRs) and regulation of gene expression. TRs have been also involved in adult brain function. In adult mice, TRα1 deletion and a dominant negative mutant receptor expression induce consistent behavioral changes leading to severe anxiety and morphological changes in the hippocampus [2].

The rT3 was about 1,000-fold less active at the thyroid hormone receptors TRα and TRβ compared with 3,3',5-triiodo-L-thyronine and commonly described as inactive [1].It has been reported that rT3 activates a native form of TRα, TRΔα1, which lacks a nuclear localization signal and functions in the cytoplasm. Through this action, rT3 initiates actin polymerization, particularly in astrocytes and neurons [3].

References:
[1] Nicod P, Burger A, Staeheli V, et al.  A radioimmunoassay for 3, 3′, 5′-triiodo-L-thyronine in unextracted serum: method and clinical results[J]. The Journal of Clinical Endocrinology & Metabolism, 1976, 42(5): 823-829.
[2] Bernal J.  Thyroid hormone receptors in brain development and function[J]. Nature clinical practice Endocrinology & metabolism, 2007, 3(3): 249-259.
[3] Senese R, Cioffi F, De Lange P, et al.  Thyroid: biological actions of ‘nonclassical’thyroid hormones[J]. Journal of Endocrinology, 2014, 221(2): R1-R12.

Chemical Properties

Cas No. 5817-39-0 SDF
别名 碘塞罗宁,Reverse T3,rT3,3,3’,5’-T3
化学名 2-amino-3-(4-(4-hydroxy-3,5-diiodophenoxy)-3-iodophenyl)propanoic acid
Canonical SMILES O=C(O)C(N)CC1=CC=C(OC2=CC(I)=C(O)C(I)=C2)C(I)=C1
分子式 C15H12I3NO4 分子量 651.0
溶解度 ≥ 32.55mg/mL in DMSO 储存条件 Store at -20°C
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1 mg 5 mg 10 mg
1 mM 1.5361 mL 7.6805 mL 15.361 mL
5 mM 0.3072 mL 1.5361 mL 3.0722 mL
10 mM 0.1536 mL 0.768 mL 1.5361 mL
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