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2'-Deoxyadenosine-5'-triphosphate (sodium salt hydrate) Sale

目录号 : GC46540

A purine nucleotide

2'-Deoxyadenosine-5'-triphosphate (sodium salt hydrate) Chemical Structure

规格 价格 库存 购买数量
25 mg
¥942.00
现货
50 mg
¥1,696.00
现货
100 mg
¥3,203.00
现货
250 mg
¥6,595.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

2'-Deoxyadenosine-5'-triphosphate (dATP) is a purine nucleotide and derivative of the nucleic acid adenosine 5'-triphosphate .1 dATP is a substrate for DNA polymerase in the synthesis of DNA.2 It is a noncompetitive inhibitor of ribonucleotide reductases, which provides feedback inhibition during DNA synthesis.1 dATP has commonly been used in DNA synthesis, sequencing, and labeling in research applications.3,4 dATP accumulates in adenosine deaminase deficiency, a disorder characterized by mutations in the gene for adenosine deaminase, the enzyme that catalyzes the deamination of adenosine and deoxyadenosine.5

1.Berg, J.M., Tymoczko, J.L., and Stryer, L.Key steps in nucleotide biosynthesis are regulated by feedback inhibitionBiochemistry(2002) 2.Berg, J.M., Tymoczko, J.L., and Stryer, L.DNA is replicated by polymerases that take instructions from templatesBiochemistry(2002) 3.Cadwell, R.C., and Joyce, G.F.Randomization of genes by PCR mutagenesisPCR Methods Appl.2(1)28-33(1992) 4.Steffens, D.L., Jang, G.Y., Sutter, S.L., et al.An infrared fluorescent dATP for labeling DNAGenome Res.5(4)393-399(1995) 5.Flinn, A.M., and Gennery, A.R.Adenosine deaminase deficiency: A reviewOrphanet J. Rare Dis.13(1)65(2018)

Chemical Properties

Cas No. N/A SDF
Canonical SMILES NC1=NC=NC2=C1N=CN2[C@@]3([H])C[C@H](O)[C@@H](COP(OP(OP(O)([O-])=O)([O-])=O)([O-])=O)O3.[Na+].[Na+].[Na+].O
分子式 C10H13N5O12P3.3Na [XH2O] 分子量 557.1
溶解度 PBS (pH 7.2): 10 mg/ml 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

制备储备液
1 mg 5 mg 10 mg
1 mM 1.795 mL 8.975 mL 17.9501 mL
5 mM 0.359 mL 1.795 mL 3.59 mL
10 mM 0.1795 mL 0.8975 mL 1.795 mL
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*在配置溶液时,请务必参考产品标签上、MSDS / COA(可在Glpbio的产品页面获得)批次特异的分子量使用本工具。

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动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系GLPBIO为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % saline
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