Home>>Signaling Pathways>> Cancer Biology>> Tumor Microenvironment>>2,3-Dimethoxy-5-methyl-p-benzoquinone
2,3-Dimethoxy-5-methyl-p-benzoquinone 目录号 GC40947

An intermediate in the synthesis of ubiquinones that has anticancer activity

规格 价格 库存 购买数量
1g
¥325.00
现货
5g
¥1,469.00
现货
10g
¥2,600.00
现货
25g
¥5,694.00
现货

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Sample solution is provided at 25 µL, 10mM.

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Chemical Properties

Cas No. 605-94-7 SDF Download SDF
别名 N/A
化学名 N/A
Canonical SMILES O=C(C(C)=C1)C(OC)=C(OC)C1=O
分子式 C9H10O4 分子量 182.2
溶解度 DMF: 100 mg/ml,DMSO: 100 mg/ml,Ethanol: 5 mg/ml,PBS (pH 7.2): 0.2 mg/ml 储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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产品描述

2,3-Dimethoxy-5-methyl-p-benzoquinone, also known as coenzyme Q0, is a key intermediate in the synthesis of coenzyme Q, coenzyme Q10, other ubiquinones, and vitamin E. It inhibits the growth of SKOV-3, A2780, and A2870/CP70 human ovarian carcinoma cells (IC50s = 26.6, 27.3, and 28.4 µM, respectively) with a cytotoxic concentration of greater than 40 µM for non-cancerous ovarian surface epithelial cells. It halts the cell cycle at the G2/M phase, increases the production of reactive oxygen species (ROS), and induces autophagy and apoptosis in SKOV-3 cells. 2,3-Dimethoxy-5-methyl-p-benzoquinone downregulates the protooncogene HER-2 and decreases the protein levels of phosphorylated AKT and mTOR in SKOV-3 cells. It also decreases the incidence of tumors and tumor burden in a SKOV-3 human ovarian carcinoma mouse xenograft model when administered at a dose of 2.5 mg/kg every four days.