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2,3-Butanedione-2-monoxime Sale

(Synonyms: 2,3-丁烷二酮一肟,BDM|Diacetyl Monoxime|NSC 660|NSC 116103) 目录号 : GC12469

A non-selective myosin ATPase inhibitor

2,3-Butanedione-2-monoxime Chemical Structure

Cas No.:57-71-6

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥368.00
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100g
¥550.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

2,3-Butanedione-2-monoxime is a myosin ATPase inhibitor.

Myosin, an ATPase, can convert chemical energy into directed movement and is regarded as a molecular motor. Myosin has various shapes and sizes. More than 11 myosin classes have been identified, and more will be found. The common feature of all of these molecules is a section close to the N terminus, which can be identified as a motor domain.

In vitro: 2,3-Butanedione-2-monoxime (BDM), a general probe of myosin function, was widely used in muscle research as a low-affinity but specific chemical phosphatase that could reversibly inhibit the myosin cross-bridge cycle. It was found that wild-type cells treated with BDM at 20 mM for around two generation times were smaller than untreated controls and showed a septation index about twice that observed in the absence of the inhibitor. Moreover, the organization of actin at the cell poles was disorganized in the presence of BDM, however, cells formed a cytokinetic actin ring. In addition, when nitrogen-starved stationary-phase cells were reinoculated into fresh medium in the presence of BDM, the time taken to repolarize the actin cytoskeleton and to resume the characteristic vegetative cell shape were both delayed substantially [1].

In vivo: So far, there is no animal in vivo data reported.

Clinical trial: So far, no clinical study has been conducted.

Reference:
[1] May KM, Wheatley SP, Amin V, Hyams JS.  The myosin ATPase inhibitor 2,3-butanedione-2-monoxime (BDM) inhibits tip growth and cytokinesis in the fission yeast, Schizosaccharomyces pombe. Cell Motil Cytoskeleton. 1998;41(2):117-25.

Chemical Properties

Cas No. 57-71-6 SDF
别名 2,3-丁烷二酮一肟,BDM|Diacetyl Monoxime|NSC 660|NSC 116103
化学名 2,3-butanedione, 2-oxime
Canonical SMILES CC(/C(C)=N/O)=O
分子式 C4H7NO2 分子量 101.1
溶解度 DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,PBS (pH 7.2): 2 mg/ml 储存条件 Store at -20°C
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1 mg 5 mg 10 mg
1 mM 9.8912 mL 49.456 mL 98.912 mL
5 mM 1.9782 mL 9.8912 mL 19.7824 mL
10 mM 0.9891 mL 4.9456 mL 9.8912 mL
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