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(±)-Felodipine-d5 Sale

(Synonyms: 非洛地平-D5) 目录号 : GC46289

An internal standard for the quantification of felodipine

(±)-Felodipine-d5 Chemical Structure

Cas No.:1242281-38-4

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1 mg
¥7,281.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

(±)-Felodipine-d5 is intended for use as an internal standard for the quantification of (±)-felodipine by GC- or LC-MS. (±)-Felodipine is an inhibitor of L-type calcium channels.1 It induces relaxation of precontracted isolated porcine coronary artery segments (EC50 = 0.15 nM), which highly express L-type calcium channels.2 (±)-Felodipine is selective for L-type calcium channels over N-, R-, and P/Q-type channels at 10 µM, as well as the T-type Cav3.2 channel (IC50 = 6.8 µM).1,3 (±)-Felodipine preferentially inhibits L-type calcium channels in isolated rat portal vein over rat left ventricle (IC50s = 33.9 and 3,981 nM, respectively).4 It decreases mean arterial blood pressure and total peripheral resistance in a rabbit model of hypertension induced by renal artery ligation when administered intravenously at doses of 30 and 100 nmol/kg.5

1.Furukawa, T., Yamakawa, T., Midera, T., et al.Selectivities of dihydropyridine derivatives in blocking Ca2+ channel subtypes expressed in Xenopus oocytesJ. Pharmacol. Exp. Ther.291(2)464-473(1999) 2.Johnson, J.D., and Fugman, D.A.Calcium and calmodulin antagonists binding to calmodulin and relaxation of coronary segmentsJ. Pharmacol. Exp. Ther.226(2)330-334(1983) 3.Perez-Reyes, E., Van Deusen, A.L., and Vitko, I.Molecular pharmacology of human Cav3.2 T-type Ca2+ channels: Block by antihypertensives, antiarrhythmics, and their analogsJ. Pharmacol. Exp. Ther.328(2)621-627(2009) 4.Ljung, B.Vascular selectivity of felodipine: Experimental pharmacologyJ. Cardiovasc. Pharmacol.15(Suppl 4)S11-S16(1990) 5.Bolt, G.R., and Saxena, P.R.Acute systemic and regional hemodynamic effects of felodipine, a new calcium antagonist, in conscious renal hypertensive rabbitsJ. Cardiovasc. Pharmacol.6(4)707-712(1984)

Chemical Properties

Cas No. 1242281-38-4 SDF
别名 非洛地平-D5
Canonical SMILES CC1=C(C(C(C(OC([2H])([2H])C([2H])([2H])[2H])=O)=C(N1)C)C2=C(C(Cl)=CC=C2)Cl)C(OC)=O
分子式 C18H14Cl2D5NO4 分子量 389.3
溶解度 Chloroform: soluble 储存条件 Store at -20°C
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1 mM 2.5687 mL 12.8436 mL 25.6871 mL
5 mM 0.5137 mL 2.5687 mL 5.1374 mL
10 mM 0.2569 mL 1.2844 mL 2.5687 mL
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