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15-acetoxy Scirpenol Sale

(Synonyms: 15-乙酰蛇形菌素) 目录号 : GC11988

A trichothecene mycotoxin

15-acetoxy Scirpenol Chemical Structure

Cas No.:2623-22-5

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1mg
¥2,925.00
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5mg
¥11,700.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

15-acetoxy Scirpenol is a trichothecene mycotoxin which is produced predominantly by members of the Fusarium genus [1]. 15-acetoxy Scirpenol could induce apoptotic cell death in human Jurkat T cells. Mycotoxins of scirpenol belong to the trichothecene family which is mainly produced by the fungal species of the genus Fusarium. Acetoxylated scirpenol has very high toxicities in animals and humans. 15-acetoxy Scirpenol exhibited cytotoxicity at a lower concentration (25 ng/ml). The 50% inhibitory concentration (IC50) values of 15-acetoxy Scirpenol was 16.1 ng/ml [2]. In the Jurkat T cells treated with 50 ng/ml of 15-acetoxyscirpenol (15-MAS), the populations of externalized PS-positive and PI-negative cells were 32.0% [2].

References:
[1] Peraica M, Radic B, Lucic A, et al.  Toxic effects of mycotoxins in humans[J]. Bulletin of the World Health Organization, 1999, 77(9): 754-766.
[2] Lee D H, Park T, Kim H W.  Induction of apoptosis by disturbing mitochondrial-membrane potential and cleaving PARP in Jurkat T cells through treatment with acetoxyscirpenol mycotoxins[J]. Biological and Pharmaceutical Bulletin, 2006, 29(4): 648-654.

Chemical Properties

Cas No. 2623-22-5 SDF
别名 15-乙酰蛇形菌素
化学名 12,13-epoxy-trichothec-9-ene-3α,4β,15-triol, 15-acetate
Canonical SMILES CC1=C[C@]2([H])[C@]([C@]([C@H](O)[C@H]3O)(C)[C@@]4(OC4)[C@]3([H])O2)(COC(C)=O)CC1
分子式 C17H24O6 分子量 324.4
溶解度 ≤10mg/ml in methanol;10mg/ml in dichloromethane 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
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1 mg 5 mg 10 mg
1 mM 3.0826 mL 15.4131 mL 30.8261 mL
5 mM 0.6165 mL 3.0826 mL 6.1652 mL
10 mM 0.3083 mL 1.5413 mL 3.0826 mL
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