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1-Palmitoyl-d9-2-hydroxy-sn-glycero-3-PC Sale

(Synonyms: 1-Hexadecanoyl-d9-sn-glycero-3-Phosphatidylcholine, 1-Hexadecanoyl-d9-sn-glycero-3-Phosphocholine, 16:0(d9) Lyso-PC, PC(16:0-d9/0:0), 16:0-d9/0:0-PC) 目录号 : GC45693

An internal standard for the quantification of 1-palmitoyl-2-hydroxy-sn-glycero-3-PC

1-Palmitoyl-d9-2-hydroxy-sn-glycero-3-PC Chemical Structure

Cas No.:1872379-72-0

规格 价格 库存
1mg
¥2,483.00
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5mg
¥9,936.00
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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

1-Palmitoyl-d9-2-hydroxy-sn-glycero-3-PC is intended for use as an internal standard for the quantification of 1-palmitoyl-2-hydroxy-sn-glycero-3-PC by GC- or LC-MS. 1-Palmitoyl-2-hydroxy-sn-glycero-3-PC is the ubiquitous lipid species generated following phospholipase A2 (PLA2) hydrolysis of phosphatidylcholine.1 It increases the production of reactive oxygen species (ROS) and decreases superoxide dismutase (SOD) and endothelial nitric oxide synthase (eNOS) protein levels and phosphorylation of ERK1/2 in human umbilical vein endothelial cells (HUVECs) when used at a concentration of 125 μM.2 1-Palmitoyl-2-hydroxy-sn-glycero-3-PC potentiates the secretion of IL-6, IL-1β, IL-12, and TNF-α in LPS-stimulated M1 macrophages, but has no effect on CD163, CD206, CD36, or IL-10 in LPS-stimulated M2 macrophages when used at concentrations of 0.3 and 1.0 μM.3 It increases TGF-β1 production and enhances Foxp3 protein levels in Treg cells in isolated human peripheral blood when used at a concentration of 10 μM.4 1-Palmitoyl-2-hydroxy-sn-glycero-3-PC enhances neutrophil function, bacterial clearance, and survival in mouse models of sepsis when administered at a dose of 10 mg/kg.5

|1. Balsinde, J., Winstead, M.V., and Dennis, E. Phospholipase A2 regulation of arachidonic acid mobilization. FEBS Lett. 531(1), 2-6 (2002).|2. Choi, S., Park, S., Liang, G.H., et al. Superoxide generated by lysophosphatidylcholine induces endothelial nitric oxide synthase downregulation in human endothelial cells. Cell Physiol. Biochem. 25(2-3), 233-240 (2010).|3. Qin, X., Qiu, C., and Zhao, L. Lysophosphatidylcholine perpetuates macrophage polarization toward classically activated phenotype in inflammation. Cell. Immunol. 289(1-2), 185-190 (2014).|4. Hasegawa, H., Lei, J., Matsumoto, T., et al. Lysophosphatidylcholine enhances the suppressive function of human naturally occurring regulatory T cells through TGF-β production. Biochem. Biophys. Res. Commun. 415(3), 526-531 (2011).|5. Yan, J.-J., Jung, J.-S., Lee, J.-E., et al. Therapeutic effects of lysophosphatidylcholine in experimental sepsis. Nat. Med. 10(2), 161-167 (2004).

Chemical Properties

Cas No. 1872379-72-0 SDF
别名 1-Hexadecanoyl-d9-sn-glycero-3-Phosphatidylcholine, 1-Hexadecanoyl-d9-sn-glycero-3-Phosphocholine, 16:0(d9) Lyso-PC, PC(16:0-d9/0:0), 16:0-d9/0:0-PC
Canonical SMILES O[C@@H](COP(OCC[N+](C)(C)C)([O-])=O)COC(CCCCCCCCCCCC([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])=O
分子式 C24H41D9NO7P 分子量 504.7
溶解度 DMF: 10 mg/ml,DMSO: 10 mg/ml,Ethanol: 10 mg/ml,PBS (pH 7.2): 10 mg/ml 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 1.9814 mL 9.9069 mL 19.8138 mL
5 mM 0.3963 mL 1.9814 mL 3.9628 mL
10 mM 0.1981 mL 0.9907 mL 1.9814 mL
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