1,2-Dioleoyl-3-linoleoyl-rac-glycerol
(Synonyms: 1,2反-油酸-3-亚油酸甘油酯,OOL) 目录号 : GC40330A triacylglycerol
Cas No.:2190-20-7
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
1,2-Dioleoyl-3-linoleoyl-rac-glycerol (OOL) is a triacylglycerol containing oleic acid at the sn-1 and sn-2 positions and linoleic acid at the sn-3 position. It is found in a variety of seed and vegetable oils, including pumpkin seed, olive, and sesame oils.[1] [2] [3]
Reference:
[1]. Ghaleb, M.L., Farines, M., and Soulier, J. Chemical composition of seed oils of pumpkin, gourd and melon. Rev. Fr. Corps Gras 38(1-2), 17-22 (1991).
[2]. Ruiz-Samblás, C., Rodríguez-Cuadros, L., González-Casado, A., et al. A straightforward quantification of triacylglycerols (and fatty acids) in monovarietal extra virgin olive oils by high-temperature GC. Anal. Methods 4(3), 753-758 (2012).
[3]. U.S.Pharmacopeia, and Formulary, N. Official Monographs NF 19; Sesame Oil. USP 24-NF 19, 3rd Supplement 19th ed., 3138-3139 (2001).
| Cas No. | 2190-20-7 | SDF | |
| 别名 | 1,2反-油酸-3-亚油酸甘油酯,OOL | ||
| 化学名 | 9Z,12Z-octadecadienoic acid 2,3-bis[[(9Z)-1-oxo-9-octadecen-1-yl]oxy]propyl ester | ||
| Canonical SMILES | CCCCCCCC/C=C\CCCCCCCC(OC(COC(CCCCCCC/C=C\C/C=C\CCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O)=O | ||
| 分子式 | C57H102O6 | 分子量 | 883.4 |
| 溶解度 | 10mg/mL in ethanol, or in DMF | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 1.132 mL | 5.66 mL | 11.3199 mL |
| 5 mM | 0.2264 mL | 1.132 mL | 2.264 mL |
| 10 mM | 0.1132 mL | 0.566 mL | 1.132 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Enantiomeric separation of asymmetric triacylglycerol by recycle high-performance liquid chromatography with chiral column
J Chromatogr A 2011 May 20;1218(20):2880-6.PMID:21429494DOI:10.1016/j.chroma.2011.02.067.
In our previous studies, we employed recycle HPLC for the separation of triacylglycerol (TAG)-positional isomers (PIs). In this study, a recycle HPLC system equipped with a polysaccharide-based chiral column was applied to the enantiomeric separation of some asymmetric TAGs having straight-chain C16-C18 acyl residues. As a result, 1,2-dipalmitoyl-3-oleoyl-rac-glycerol (rac-PPO), 1,2-dioleoyl-3-palmitoyl-rac-glycerol (rac-OOP), and 1,2-dipalmitoyl-3-linoleoyl-rac-glycerol (rac-PPL) were resolved into their respective enantiomers. However, neither 1,2-Dioleoyl-3-linoleoyl-rac-glycerol (rac-OOL), consisting of only unsaturated fatty acids, nor 1,2-dipalmitoyl-3-stearoyl-rac-glycerol (rac-PPS), consisting of only saturated fatty acids, was resolved. These results suggest that the asymmetric TAGs, used in this study, having both a palmitic acid moiety and an oleic acid (or a linoleic acid) moiety at the sn-1 or sn-3 positions are resolved by the chiral column. This new chiral separation method can be used in combination with atmospheric pressure chemical ionization mass spectrometry to determine the sn-OOP/sn-POO ratio in palm oil. This method is applicable for the chiral separation of asymmetric TAGs in palm oil.
Research on the effect of spleen-invigorating and anti-swelling active ingredients in crude and processed coix seed based on Spectrum - Effects relationship combined with chemometrics
J Pharm Biomed Anal 2021 Oct 25;205:114350.PMID:34507270DOI:10.1016/j.jpba.2021.114350.
Coix seed (CS) is the dry mature seed kernel of Coix lacrma-jobi L. var. mayuen (Roman.) Stapf, which has the effect of spleen-invigorating and anti-swelling. However, research reports on the main active ingredients of CS were minimal. The purpose of this study was to find the main active ingredients that affect the efficacy of CS to invigorate the spleen and reduce swelling through the spectrum-effect relationship, combined with chemometrics, grey relational analysis (GRA) and entropy method, and to compare the differences between the effects of crude and processed CS. First of all, the HPLC-ELSD method was used to establish the chromatographic fingerprint of CS, and 12 batches of CS samples were analyzed through chemometrics in this study. Then, we studied the effect of spleen-invigorating and anti-swelling in CS. Finally, through grey relational analysis and entropy method, the spectrum-effect relationship between the chromatographic fingerprint and the seven pharmacodynamic effect indexes was studied. The results showed that the main pharmacologically active ingredients were 1,3-Dioleoyl-2-palmitoylglycerol (peak 8), 1,2-dilinoleoyl-3-oleoyl-rac-glycerol (peak 2), 1,3-Dipalmitoyl-2-Linolein (peak 5), 1,2-Dilinoleoyl-3-palmitoyl-rac-glycerol (peak 3), 1,2-Dioleoyl-3-linoleoyl-rac-glycerol (peak 4), and glycerol trioleate (peak 7), and the comprehensive efficacy of bran-fried CS was better than that of raw CS. In summary, we have identified the main active ingredients related to the efficacy of CS. As far as we know, this is the first time that the crude and processed CS spectrum-effect relationship has been established and compared, which provides a theoretical basis for subsequent studies on the material basis and molecular mechanism of CS pharmacodynamics.